Mary Cunningham

George Mason becomes new home for 400,000 biological specimens from Inova Health Systems

Mary Cunningham — Wed, 17 Jul 2024 00:07:11 +0000

George Mason becomes new home for 400,000 biological specimens from Inova Health Systems Mary Cunningham Tue, 07/16/2024 - 20:07

��AV’s College of Public Health is the new home of 400,000 biological specimens through a partnership with Inova Health Systems. This repository of specimens, called a biobank, is an extensive collection of obstetrical and perinatal samples, along with follow-up health information, providing a rare and invaluable asset in public health and in the education of our future health, science, and technology care workforce.

“The biorepository creates opportunities for Mason to expand its collaborations with Inova, biotechnology partners, and other universities in Virginia, as well as unique educational opportunities,” said Melissa Perry, dean of the college.

Larry Maxwell, president of the Women’s Service Line at Inova Health System, said, “The investment by Inova Health System as well as additional support from the Fairfax County Government have created an unprecedented resource of placenta as well as blood specimens from mother, father, and baby [trios] corresponding to over 4,000 families. These biospecimens and corresponding data continue to support scientific research to better understand the obstetrical diseases that contribute to rising rates of maternal morbidity and mortality locally, regionally, and nationally.”

A range of specimens (e.g., saliva, urine, and blood) were collected with consent from an Inova cohort study that followed more than 4,000 women, their partners, and their children from pregnancy into early childhood to examine maternal health, pregnancy outcomes, and children’s growth and development.

Biobank program leads Carolyn Drews-Botsch and Michael S. Bloom. Photo by Evan Cantwell/Office of University Branding

“The transfer of the biobank from Inova Health System to the College of Public Health serves as a testament to our strong public–private partnership, and underscores George Mason’s dedication to advancing health in pregnancy and early childhood,” said Alison Cuellar, College of Public Health associate dean for research. The biobank is housed at the university’s Science and Technology Campus in Manassas, Virginia.

The biobank offers an unprecedented opportunity for George Mason researchers to engage with and involve Virginia’s undergraduate and graduate students in health and public health science, to expand Virginia’s health, science, and technology workforce pipeline and enhance its diversity.

“The availability of such comprehensive and diverse datasets within a single biobank is rare, making it an attractive asset for collaboration and groundbreaking research endeavors,” said Michael S. Bloom, program lead of the College of Public Health Biobank and George Mason professor.

Space at the SciTech Campus for the biobank was renovated to hold the 11 tanks (called dewars) and freezers full of specimens. Photo by Evan Cantwell/Office of University Branding

Bloom and co-lead Carolyn Drews-Botsch started the work for the biobank transfer in 2021. Inova chose Bloom and Drews-Botsch after extensive vetting of their prior research experience, including involvement in large cohort studies, such as those from which these specimens are drawn. Space at the SciTech Campus for the biobank was renovated to hold the 11 tanks (called dewars) and freezers full of specimens. The containers are kept between -80 degrees C and -190 degrees C to maintain specimen integrity during long-term storage.

“These specimens will be vital for public health researchers who are looking to identify associations and factors that support healthy pregnancy and child health and ultimately benefit the public’s health,” said Drews-Botsch, a professor in the College of Public Health.

The professors expect the biobank to become a leading resource for collaborative projects once a research database is developed, with other researchers analyzing the data to answer important public health questions.

“By actively fostering these partnerships, George Mason can position itself as a leader in research around maternal health and early childhood and contribute to the advancement of public health on a larger scale,” Perry said.

Uncover more research at the College of Public Health

In This Story

Michael S. Bloom, PhD, MS, FACE

Carolyn Drews-Botsch, PhD, MPH

Alison Evans Cuellar, PhD, MBA

Melissa J. Perry, Sc.D., MHS

Topics

Maternal Child Health

Songs from adolescence and early adulthood enhance mood and social engagement among people with dementia, according to new study

Mary Cunningham — Mon, 24 Jun 2024 21:18:46 +0000

Songs from adolescence and early adulthood enhance mood and social engagement among people with dementia, according to new study Mary Cunningham Mon, 06/24/2024 - 17:18

Around 46% of residents in U.S. nursing homes have Alzheimer's or other dementias, and 13% of them are treated with antipsychotic medications, according to the National Partnership to Improve Dementia Care in Nursing Homes.

Photo by Getty Images

Antipsychotic medications that affect a person’s mental state have been widely prescribed for people living with dementia in nursing facilities to treat their behavioral (social) and psychological (mood) symptoms, though positive results are limited, and the drugs can come with serious side effects. ��AV College of Public Health faculty are part of a growing group of researchers who are seeking therapeutic ways to improve the quality of life of these residents without medication.

New research, led by principal investigator Megumi Inoue, found that personalized music intervention is effective at reducing the use of antipsychotic and antianxiety medication, alleviating agitation levels, and enhancing mood and social engagement among residents.

Personalized playlists were developed based on family member suggestions regarding what songs, artists, and/or genres the participants listened to when they were around 15 to 25 years old, an age when more memories are available for potential recollection. Facility staff played the personalized playlists for the intervention group twice a week, aiming for at least 30 minutes each session, for four weeks. Participants in the control group continued their usual schedule during these four weeks.

Associate Professor of Social Work Megumi Inoue

“This study provides evidence that personalized music intervention can be used to manage distressing behavioral and psychological symptoms associated with dementia,” said Inoue, an associate professor in the Department of Social Work. "This low-cost, easily implementable intervention, requiring no special licensure for administration, can significantly enhance the quality of life for nursing facility residents

Overall, the intervention group experienced a decrease in average antipsychotic medication use after the intervention, and the control group, which did not receive any music, had an increase in medication use during the same time period. The observational data also revealed that this intervention can improve the mood of residents living with dementia and help them connect with others, while surveys from administrative staff and activity directors highlighted their positive views of the intervention.

“In addition to improving patients’ quality of life, this intervention can create an improved environment throughout the nursing home,” said Inoue. "For example, if personalized music helps reduce residents’ challenging symptoms, they will become easier to work with for direct care workers. In addition, the reduction of medications to treat residents’ psychological and behavioral symptoms will contribute to creating an overall safer facility because such medications have sedating effects that can cause falls."

She added, "Using the personalized music intervention may be perceived as extra work by some staff members, but ultimately, it can ease their work processes as its positive effects have indirect impacts on their work and facility environment."

“A Personalized Music Intervention in Nursing Home Residents Living With Dementia: Findings From a Randomized Study” was published online in the Journal for Applied Gerontology in June 2024. This research was supported by a Civil Money Penalty (CMP) Fund from the Centers for Medicare and Medicaid Services through the Virginia Department of Medical Assistance Services.

Additional authors include Emily S. Ihara, Catherine J. Tompkins, Shannon Layman, Sarah Nosrat, Morgan Moore, and Kimberly A. McNally from George Mason’s College of Public Health; Meng-Hao Li from George Mason’s Schar School of Policy and Government; Samreen Mehak from George Mason’s Department of Biology; George Mason alumna Kendall Barrett from Wise Mind Psychotherapy; and Catherine Magee from Paving the Way MSI.

In This Story

Megumi Inoue, PhD

Topics

Virginia Department of Medical Assistance Services

Research

College of Public Health

In the George

College of Public Health receives NIH grant to pilot AI chatbot for African Americans with depression

Mary Cunningham — Mon, 10 Jun 2024 17:03:05 +0000

College of Public Health receives NIH grant to pilot AI chatbot for African Americans with depression Mary Cunningham Mon, 06/10/2024 - 13:03

In This Story

Farrokh Alemi, PhD

Janusz Wojtusiak, PhD

Kevin Lybarger

As a leader in innovative health solutions, ��AV’s College of Public Health received a National Institutes of Health (NIH) AIM-AHEAD program grant to pilot an artificial intelligence (AI) chatbot for Black and African Americans with depression. Professor Farrokh Alemi will enhance his first-of-its-kind, evidence-based artificial intelligence tool to address the medication needs of African Americans with depression.

Professor of Health Informatics Farrokh Alemi

The existing AI tool recommends antidepressants for 16,775 general-population patient subgroups, each representing a unique combination of medical history. For each of these subgroups, the current project will analyze the effectiveness and appropriateness of the recommendations for African Americans, using the NIH All of Us database and existing published literature.

To the researchers' knowledge, this is the first research focused on developing and evaluating an antidepressant recommendation system for Black and African American people.

“Antidepressant medications are a first-line treatment for depression; however, a majority of depressed patients do not experience improvement with their first antidepressant. Additionally, minority populations, including Black and African Americans, are not well represented in antidepressant studies, contributing to reduced antidepressant effectiveness in these populations,” said Alemi. “There is a significant need to synthesize available evidence regarding antidepressant effectiveness and provide personalized treatment recommendations, and this project addresses a major gap in the management of Black and African Americans with depression.”

Researchers will develop a Knowledge-enhanced Antidepressant Recommendation Dialogue System (KARDS), which will engage users in a back-and-forth conversation to acquire the patient information needed to identify the appropriate antidepressant medication. The AI will provide the patient with a list of recommended medications, list of the relevant studies, and an explanation for the medication decisions. The system will automatically send the patient’s clinician a brief point-of-care recommendation and explanation, with an option to examine a complete record of the conversation and the supporting evidence.

“Chatbots—or patient-facing dialogue systems like the one we will create—hold transformative potential for the health care sector and are increasingly prominent in psychiatric applications, predominantly through therapy-bot implementations,” said Alemi. “Our chatbot will help improve the detailed, time-consuming, medical history intake process, and provide point-of-care summary and prescription recommendations to the patients’ clinicians. The chatbot will make patients more comfortable because the natural language modality provides an intuitive, empathetic, stigma-free interface.”

Once the AI chatbot is developed, the team will test the dialogue system with Black and African American patients to evaluate system functionality and user preferences. Additionally, the project will train a Black or African American doctoral or master’s student in AI, expanding the available workforce and building the community’s capacity to address AI.

Alemi will lead the research team, which includes Janusz Wojtusiak, a George Mason professor of Health Informatics and the director of the Machine Learning and Inference Laboratory, and Kevin Lybarger, a George Mason assistant professor in the Department of Information Sciences and Technology in the College of Engineering and Computing. All three members have collaborated previously to diagnose COVID at home from presenting symptoms.

The $70,906 grant is part of the NIH’s AIM-AHEAD (Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity) program, which aims “to establish mutually beneficial and coordinated partnerships to increase the participation and representation of researchers and communities currently underrepresented in the development of AI/machine learning models and enhance the capabilities of this emerging technology, beginning with electronic health record data.”

Innovate for Good is an ongoing series that examines how George Mason faculty in the College of Public Health are harnessing technology to improve health outcomes.

If you have stories to share as part of the Innovate for Good series, email Mary Cunningham at mcunni7@gmu.edu.

Topics

Artifical Intelligence

Tech Talent Investment Program (TTIP)

New research describes the leisure motivations that underpin young U.S. adults' recreational cannabis use

Mary Cunningham — Mon, 10 Jun 2024 15:40:21 +0000

New research describes the leisure motivations that underpin young U.S. adults' recreational cannabis use Mary Cunningham Mon, 06/10/2024 - 11:40

In This Story

Iulia Fratila, PhD

As of 2024, 24 states including Virginia, Maryland, and Washington, D.C., have legalized the adult recreational use of cannabis. As laws change, citizens' perceptions of the drug and reasons for using the drug have also shifted. In 2020, 34.5% of adults aged 18–25 reported using cannabis in the previous 12 months, according to the Substance Abuse and Mental Health Services Administration. Health experts seek to better understand the broader implications of legalization and individuals’ motivations and attitudes related to cannabis use.

Iulia Fratila, assistant professor in ��AV’s College of Public Health

New qualitative research by Iulia Fratila, assistant professor in ��AV’s College of Public Health, and Liza Berdychevsky, associate professor at the University of Illinois Urbana–Champaign, describes in what ways young adults (aged 18–30) view cannabis as a recreational and leisure pursuit.

“Recreational cannabis legalization and liberalization is shifting across U.S. states. More holistic approaches to understanding perceptions of cannabis benefits and leisure motivations are scarce due to the longstanding criminalization of cannabis,” said Fratila, the principal investigator. “This research provides novel insights into cannabis users' leisure motivations of use and perceived benefits, which can be leveraged strategically in public health and drug education efforts in the societal transition from criminalization to normalization and commercialization trends concerning cannabis.”

Participants in Fratila and Berdychevsky’s study suggest cannabis can offer a leisure state of mind (e.g., experiencing flow, relaxation, and meditative state), as well as represent a leisure pursuit reserved for free time (e.g., using cannabis as a reward for free, post-obligations time outside of daily demands). Additionally, participants described how cannabis serves as a leisure activity itself (i.e., the act of getting high) and/or as an activity that accompanies other leisure pursuits and socialization (e.g., getting high and going to the movies), while providing pleasurable outcomes (e.g., feeling enjoyment, engaging in humor, enhancing senses).

“Participants discussed the ways that their recreational cannabis consumption represents a controlled and calculated risk-benefit leisure choice that is successfully managed for their overall well-being. Their narratives highlight that this perceived leisure pursuit does not necessarily interfere with their otherwise productive lives,” said Fratila.

These insights can inform harm reduction approaches to cannabis education that may be more effective considering the cannabis legalization and liberalization landscape. Health educators and health promoters can discuss cannabis risks and potential negative health outcomes while acknowledging the desired benefits cannabis users anticipate.

Fratila warns about the impacts of widespread legalization and the emerging recreational cannabis markets, which highlights another meaningful implication connected to the study findings. “Under prohibitory regulations, recreational cannabis use has been explicitly framed as deviant, criminal, harmful, life-wrecking, and void of any potentially desirable leisure qualities (e.g., pleasure, socialization). This study showcases the cannabis users’ understanding of cannabis as normative recreation and the anticipated leisure benefits,” said Fratila.

She further explained, “However, this is a cautionary tale because these desirable qualities may be easily exploited. More specifically, society may be facing a new conundrum with the commercialization of recreational cannabis as the switch from criminalization to commercialization overly simplifies and glamorizes the leisure meanings of cannabis for profitable gain.”

Public health experts and scholars will need to be at the front lines, in collaboration with other fields, to monitor how cannabis is repositioned and accommodated in a cannabis-friendly society, according to Fratila. Specifically, it will be important to spearhead effective health promotion efforts that minimize any related harms and maximize well-being.

This was a qualitative research project utilizing hermeneutic phenomenology, a research method to study how experiences affect everyday practices, and in-depth interviewing with 16 individuals (ages 18–30) living in the U.S. states with legalized recreational cannabis.

“Phenomenological Exploration of Young Adults’ Recreational Cannabis Use Experiences and Associated Leisure Meanings” was published in the Journal of Leisure Research in June 2024. This research was not funded.

Topics

George Mason researchers harness the power of artificial intelligence to match patients with the most effective antidepressant for their unique needs

Mary Cunningham — Wed, 29 May 2024 19:46:58 +0000

George Mason researchers harness the power of artificial intelligence to match patients with the most effective antidepressant for their unique needs Mary Cunningham Wed, 05/29/2024 - 15:46

Researchers in ��AV’s College of Public Health have leveraged the power of artificial intelligence (AI) analytical models to match a patient’s medical history to the most effective antidepressant, allowing patients to find symptom relief sooner. The free website, MeAgainMeds.com, provides evidence-based recommendations, allowing clinicians and patients to find the optimal antidepressant the first time.

Farrokh Alemi, principal investigator and professor of health informatics at ��AV’s College of Public Health

“Many people with depression must try multiple antidepressants before finding the right one that alleviates their symptoms. Our website reduces the number of medications that patients are asked to try. The system recommends to the patient what has worked for at least 100 other patients with the same exact relevant medical history,” said Farrokh Alemi, principal investigator and professor of health informatics at ��AV’s College of Public Health.

AI helped to simplify the very complex task of making the thousands of guidelines easily accessible to patients and clinicians. The guidelines that researchers created are complicated because of the amount of clinical information that is relevant in prescribing an antidepressant; AI seamlessly simplifies the task.

With AI at its core, MeAgainMeds.com analyzes clinician or patient responses to a few anonymous medical history questions to determine which oral antidepressant would best meet the specific needs. The website does not ask for any personal identifiable information and it does not prescribe medication changes. Patients are advised to visit their primary health care provider for any changes in medication.

In 2018, the Centers for Disease Control reported that more than 13% of adults use antidepressants, and the number has only increased since the pandemic and other epidemics since 2020. This website could help millions of people find relief more quickly.

Alemi and his team analyzed 3,678,082 patients who took 10,221,145 antidepressants. The oral antidepressants analyzed were amitriptyline, bupropion, citalopram, desvenlafaxine, doxepin, duloxetine, escitalopram, fluoxetine, mirtazapine, nortriptyline, paroxetine, sertraline, trazodone, and venlafaxine. From the data, they created 16,770 subgroups of at least 100 cases, using reactions to prior antidepressants, current medication, history of physical illness, history of mental illness, key procedures, and other information. The subgroups and remission rates drive the AI to produce an evidence-based medication recommendation.

“By matching patients to the subgroups, clinicians can prescribe the medication that works best for people with similar medical history,” said Alemi. The researchers and website recommend that patients who use the site take the information to their clinicians, who will ultimately decide whether to prescribe the recommended medicine.

Alemi and his team tested a protype version of the site in 2023, which they advertised on social media. At that time, 1,500 patients used the website. Their goal is to improve the website and expand its user base. The initial research was funded by the Commonwealth of Virginia and by the Robert Wood Johnson Foundation.

The researchers’ most recent paper in a series of papers on response to antidepressants analyzed 2,467 subgroups of patients who had received psychotherapy. “Effectiveness of Antidepressants in Combination with Psychotherapy” was published online in March 2024. Additional authors include Tulay G Soylu from Temple University, and Mary Cannon and Conor McCandless from Royal College of Surgeons in Dublin, Ireland.

In This Story

Farrokh Alemi, PhD

Discover more Research from the College of Public Health

Topics

Artificial Intelligence

Tech Talent Investment Pipeline (TTIP)

TTIP

Tech Talent Investment Program

Research

In the George

Mason CARES intervention reduces stress and feelings of burden of family caregivers of older adults with dementia

Mary Cunningham — Wed, 29 May 2024 15:50:53 +0000

Mason CARES intervention reduces stress and feelings of burden of family caregivers of older adults with dementia Mary Cunningham Wed, 05/29/2024 - 11:50

In This Story

Dr. Cathy Tompkins

Gilbert Gimm, PhD

According to the U.S. Centers for Disease Control and Prevention, 80% of those living with dementia receive informal care from family members or friends. This equates to 16 million family caregivers in the U.S. However, caring for family members with dementia is often associated with increased caregiver burden (which includes emotional, physical, and financial strain), stress, and worse physical health for the caregiver.

Catherine Tompkins, principal investigator, professor of social work, and associate dean of faculty and staff affairs in the College of Public Health.

A recent study published in the Journal of Applied Gerontology, led by ��AV researchers, found that a 9-week online stress management intervention program for family caregivers reduced burden scores by 15% for 97 family caregivers of older adults living with dementia. The Stress-Busting Program for Family Caregivers TM, intervention was specifically designed to help family caregivers manage their own stress when caring for older adults living with dementia or a chronic illness

“In this study, we found evidence of a range in average caregiver burden levels based on the dementia severity category of care recipients. The findings show that an online Zoom intervention in a peer group setting can be beneficial for family caregivers of older adults with mild, moderate, or severe dementia,” said Catherine Tompkins, principal investigator, professor of social work, and associate dean of faculty and staff affairs in the College of Public Health.

The intervention provided family caregivers with education and strategies to manage stress when caring for someone living with dementia. Examples of self-care techniques included breathing and meditation; troubleshooting behaviors associated with dementia; and peer-to-peer support within a virtual group setting.

Associate Professor Gilbert Gimm

“Reducing caregiver burden and managing stress are critical to the well-being of families. These findings show that effective stress management interventions for family caregivers can be facilitated through online peer groups,” said Gilbert Gimm, first author and associate professor of health administration and policy.

“Mason Caregivers Aiming for Resilience, Empowerment, and Support Study: Assessing Family Caregiver Burden Post-Intervention” was published online in April 2024. Co-authors include George Mason Associate Professor Megumi Inoue, Professor Emily Ihara, Mason CARES Project Manager Shannon Layman, and Master of Social Work alumna graduate Harveen Pantleay. This study was supported by a grant (#2021048) from the Retirement Research Foundation (RRF).

The study is part of a larger project, entitled Mason CARES (Caregivers Aiming for Resilience, Empowerment, and Support), that implemented and assessed interventions for family caregivers.

Topics

Should I be worried about bird flu? Everything you need to know

Mary Cunningham — Wed, 22 May 2024 15:13:12 +0000

Should I be worried about bird flu? Everything you need to know Mary Cunningham Wed, 05/22/2024 - 11:13

Professor Amira Roess

In April, the World Health Organization confirmed a case of Avian influenza A (H5N1), commonly known as bird flu, in a human in Texas. The individual contracted the disease while working on a commercial dairy cattle farm where the cows are believed to have been infected. The individual reported only minor symptoms and is the first confirmed human case in 2024. A second case of bird flu was reported in a human in May 2024. Cases of bird flu in cattle and other animals have now been found in Idaho, Kansas, Michigan, New Mexico, Ohio, Texas, and other states.

Reports have emerged that virus particles have been found in milk, but it is important to note that the virus particles are not infectious in pasteurized milk. Global organizations continue to monitor the situation as it evolves.

Amira Roess, professor of global health and epidemiology, offers insight and clarity on the uncertainties of this early disease outbreak. Roess is an epidemiologist who studies emerging zoonotic infectious diseases and their risk factors. Her research is interdisciplinary and includes complex longitudinal studies throughout the world. She served as the science director of the Pew policy commission on Industrial Food Animal Production and also served as a consultant on preparedness and response to H5N1 in 2007.

Should I be worried about bird flu right now?

Right now, most individuals do not need to be particularly worried about this strain of influenza because it is not affecting large numbers of people. There are many actions being taken to protect humans and to limit the impact of this virus on both our food supply and on people. For example, surveillance of animals has ramped up in response to the growing epidemic in animals. As infected animals are being identified, they are removed from the food supply before they can spread the virus.

Should we be worried that the current outbreak will spread?

Several agencies are closely monitoring the situation. So far this year, cows, birds, and one person in the U.S. have been infected with the virus. Influenza viruses are notorious for their ability to mutate. We have limited knowledge of cow viruses adapting to humans so the mutations must be monitored closely for any changes that may occur that make the virus more transmissible or more dangerous to humans. If changes occur, early interventions can be put in place, including the development of tailored, vaccines.

We have decades of experience monitoring influenza and H5N1 in particular. What we have seen time and time again is that surveillance of human, animal, and environmental samples is extremely important. Surveillance allows us to identify new viral strains that may have public health importance before they cause large numbers of severe illness and death in both people and animals.

Is milk safe to drink even though the virus has been found in milk?

Here I will emphasize the pasteurized milk is safe for consumption. There have been reports of cats being fatally infected with this strain of influenza after consuming contaminated raw milk.

Testing by the FDA and USDA has not detected any live viruses in retail pasteurized dairy products like cheese, sour cream, or milk powders. Essentially, this means that while viral particles have been detected in pasteurized dairy products, including milk, these are not infectious. The bottom line is that pasteurization is effective in inactivating potentially live strains of bird flu.

To speak to Amira Roess about bird flu or other emerging diseases, please contact Michelle Thompson at mthomp7@gmu.edu

Amira Roess is a professor of global health and epidemiology at ��AV's College of Public Health, Department of Global and Community Health. She is an epidemiologist with expertise in infectious diseases epidemiology, multidisciplinary and multi-species field research and evaluating interventions to reduce the transmission and impact of infectious diseases. Roess currently oversees several longitudinal studies to understand emergence and transmission of zoonotic infectious diseases globally, including the emergence and transmission of Campylobacter (with support from The Bill and Melinda Gates Foundation), MERS-CoV (with support from the U.S. National Science Foundation), and the development of the microbiome during the first year of life. She studies links between food animal production and emerging infectious and zoonotic diseases emergence globally, and mHealth (especially apps) technology integration and evaluations to reduce the impact of infectious disease outbreaks, promote health care, and help reduce disparities.

About George Mason University

��AV is Virginia’s largest public research university. Located near Washington, D.C., Mason enrolls more than 40,000 students from 130 countries and all 50 states. Mason has grown rapidly over the past half-century and is recognized for its innovation and entrepreneurship, remarkable diversity, and commitment to accessibility. In 2023, the university launched Mason Now: Power the Possible, a one-billion-dollar comprehensive campaign to support student success, research, innovation, community, and stewardship. Learn more at gmu.edu.

About College of Public Health at ��AV

The College of Public Health at ��AV is the first and only College of Public Health in Virginia combining public health transdisciplinary research, education, and practice in the Commonwealth as a national exemplar. The College enrolls more than 1,900 undergraduate and 1,300 graduate students in our nationally recognized programs, including six undergraduate degrees, eight master’s degrees, five doctoral degrees, and six professional certificate programs. The College is comprised of the School of Nursing and the Departments of Global and Community Health, Health Administration and Policy, Nutrition and Food Studies, and Social Work.

In This Story

Amira Roess, PhD, MPH

Topics

George Mason receives $1.2 million to revolutionize Lyme disease testing

Colleen Rich — Wed, 15 May 2024 18:42:12 +0000

George Mason receives $1.2 million to revolutionize Lyme disease testing Colleen Rich Wed, 05/15/2024 - 14:42

��AV researchers have received $1.2 million in federal funding from the U.S. Department of the Army to revolutionize Lyme disease detection and diagnosis with urine testing. Scientists from George Mason’s College of Science and College of Public Health aim to harness the many advantages of urine testing over other methods and increase mainstream adoption.

Photo by Getty Images

“We have developed a urine test for Lyme disease that detects the bacteria (Borrelia species) that causes Lyme disease, making it a direct test to confirm an infection soon after the tick bite,” said principal investigator Alessandra Luchini. "This leads to earlier treatment when necessary and could prevent the long-term debilitating effects of the disease.”

The current standard of care test for potential Lyme disease is an antibody blood test, which measures the immune system response to the bacteria that cause Lyme disease. In contrast, the George Mason test detects molecules derived from the bacteria themselves, which have the advantage of high specificity (accuracy) and early detection. The test matches the exact amino acid sequences (the building blocks of the bacterial molecules) that are found only in Borrelia and not in other organisms. For example, one of the proteins the George Mason scientists studied is part of the Borrelia flagellum, which allows the bacterium to move around the body.

In Mason’s clinical research trials, urine tests had a 90% true positive rate (sensitivity) and close to 100% specificity (true negative rate).

Researchers will use banked samples from cross-sectional and longitudinal studies of acute Lyme patients from the Lyme Disease Biobank and banked specimens from Johns Hopkins University, respectively, who are recognized leader in clinical Lyme disease research.

Utilizing her 15 years of Lyme disease bacteria (Borrelia) research, Ashley Groshong, PhD, unit chief of the Bacterial Physiology and Metabolism Section of the National Institute of Allergy and Infectious Diseases, a part of the National Institutes of Health, is collaborating on the project by evaluating the suitability of diagnostic indicators based on bacterial physiology.

Additionally, the George Mason study will pilot a collapsible urine collection cup shipped to a lab through the mail, making collection and diagnosis easier for more people to access through telehealth.

"A urine cup will offer a private, comfortable and convenient way to collect the sample at home without compromising the accuracy of the lab test,” said Lance Liotta, professor in the College of Science, co-director of Mason’s Center for Applied Proteomics and Molecular Medicine, and co-principal investigator on the study. “Shipped in a semi-dry state that will preserve target proteins and protects again specimen degradation, this approach will improve specificity, which has been a weakness of previous testing approaches."

Lyme disease is the most common animal-to-human transmitted disease in the United States with approximately 476,000 people diagnosed and treated each year—and it is on the rise. If not treated quickly and properly, those bitten can suffer from prolonged symptoms (called Post-Treatment Lyme Disease Syndrome), such as concentration and memory issues, dizziness, fatigue, body aches, depression, and difficulty sleeping.

“This is a significant collaboration to advance diagnostics for Lyme disease,” said Melissa J. Perry, dean of the College of Public Health and co-investigator of the study. “This study will have a major impact on the timely diagnosis of Lyme. In my capacity as an epidemiologist, I am thrilled to work with Drs. Luchini, Liotta, and [Virginia] Espina, and Dr. [Jenna] Krall in her capacity as a biostatistician.”

This three-year study will take place in the same Mason CAP/CLIA Clinical Proteomics Laboratory that implemented the innovative saliva COVID test. The lab is run by Espina, who is a collaborator on the grant.

In 2022, Luchini, Liotta, and the CAPMM team were one of 10 Phase 1 winners of the LymeX Diagnostics Prize by the U.S. Department of Health and Human Services and the Steven and Alexandra Cohen Foundation.

In early 2023, CAPMM received $820,000 in federal funding to establish a clinic that will help combat Lyme disease and other tick-borne illnesses. The project, championed by U.S. Representative Jennifer Wexton, was part of the federal omnibus appropriations bill that President Biden signed into law to fund the government through Fiscal Year 2023. The federal funds will be used to launch the clinical deployment of diagnostic testing that will allow for a quicker and more efficient diagnosis.

This work will be supported by the Assistant Secretary of Defense for Health Affairs through the Tick-Borne Disease Research Program, endorsed by the Department of Defense. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.

Did you know...

George Mason's Lyme disease test started as a student project in the Aspiring Scientists Summer Internship Program. Watch our original discussion with Temple Douglas on our YouTube channel.

Build your own research experience with ASSIP

Topics

Research

College of Public Health

College of Science

Center for Applied Proteomics and Molecular Medicine (CAPMM)

Strategic Direction

Mason Momentum

��AV receives over $1.1 million to revolutionize Lyme disease testing

Mary Cunningham — Wed, 24 Apr 2024 22:02:01 +0000

��AV receives over $1.1 million to revolutionize Lyme disease testing Mary Cunningham Wed, 04/24/2024 - 18:02

With tick bites on the rise, College of Science and College of Public Health are collaborating to improve detection, diagnosis, and treatment with urine testing

��AV researchers have received a $1,176,645 grant in federal funding from the U.S. Department of the Army to revolutionize Lyme disease detection and diagnosis with urine testing. The College of Science and College of Public Health aim to harness the many advantages of urine testing over other methods and increase mainstream adoption.

Alessandra Luchini, systems biology professor in the College of Science and Mason’s principal investigator.

“We have developed a urine test for Lyme disease that detects the bacteria (Borrelia species) that causes Lyme disease, making it a direct test to confirm an infection soon after the tick bite. This leads to earlier treatment when necessary and could prevent the long-term debilitating effects of the disease,” said Alessandra Luchini, systems biology professor in the College of Science and George Mason’s principal investigator.

The current standard of care test for potential Lyme disease is an antibody blood test, which measures the immune system response to the bacteria that cause Lyme disease. In contrast, the Mason test detects molecules derived from the bacteria themselves, which have the advantage of high specificity (accuracy) and early detection. The Mason test matches the exact amino acid sequences (the building blocks of the bacterial molecules) that are found only in Borrelia and not in other organisms. For example, one of the proteins the Mason scientists studied is part of the Borrelia flagellum, which allows the bacterium to move around the body.

In Mason’s clinical research trials, urine tests had a 90% true positive rate (sensitivity) and close to 100% specificity (true negative rate). Researchers will use banked samples from cross-sectional and longitudinal studies of acute Lyme patients from the Lyme Disease Biobank and banked specimens from Johns Hopkins University, respectively, who are recognized leader in clinical Lyme disease research.

Additionally, the Mason study will pilot a collapsible urine collection cup shipped to a lab through the mail, making collection and diagnosis easier for more people to access through telehealth.

Lance Liotta, professor in the College of Science, co-director of Mason’s Center for Applied Proteomics and Molecular Medicine, and co-investigator on the study.

"A urine cup will offer a private, comfortable and convenient way to collect the sample at home without compromising the accuracy of the lab test,” said Lance Liotta, professor in the College of Science, co-director of Mason’s Center for Applied Proteomics and Molecular Medicine, and co-investigator on the study. “Shipped in a semi-dry state that will preserve target proteins and protects again specimen degradation, this approach will improve specificity which has been a weakness of previous testing approaches."

Melissa J. Perry, dean of the College of Public Health and co-investigator of the study.

“This is a significant collaboration to advance diagnostics for Lyme disease. In my capacity as an epidemiologist, I am thrilled to work with Drs. Luchini, Liotta, and Espina, and Dr. Krall in her capacity as a biostatistician. This study will have a major impact on the timely diagnosis of Lyme,” said Melissa J. Perry, dean of the College of Public Health and co-investigator of the study.

This three-year study will take place in the same Mason CAP/CLIA Clinical Proteomics Laboratory that implemented the innovative saliva COVID test. The lab is run by Virginia Espina, who is a collaborator on the grant.

This work will be supported by the Assistant Secretary of Defense for Health Affairs through the Tick-Borne Disease Research Program, endorsed by the Department of Defense. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.

About ��AV
��AV is Virginia’s largest public research university. Located near Washington, D.C., Mason enrolls more than 40,000 students from 130 countries and all 50 states. Mason has grown rapidly over the past half-century and is recognized for its innovation and entrepreneurship, remarkable diversity, and commitment to accessibility. In 2023, the university launched Mason Now: Power the Possible, a one-billion-dollar comprehensive campaign to support student success, research, innovation, community, and stewardship. Learn more at gmu.edu.

About the College of Science
Mason’s College of Science is a leader in scientific discovery and a creator of innovative solutions for the rapidly-changing needs of today’s world. The college prides itself in being home to a diverse population of more than 4,200 students and researchers serving as a magnet for all scientific minds. With new discoveries, our scientists continue to grow Mason’s portfolio of patents, licenses, partnerships, and spin off companies.

The college blends traditional science education with sought-after programs at all levels across a dozen departments to challenge and engage in disciplines including personalized medicine, infectious diseases, drug discovery, climate dynamics, environmental justice and conservation, materials science, astronomy, forensic science, computational science, and applied mathematics. Learn more at science.gmu.edu.

About the College of Public Health
Mason’s College of Public Health—the first College of Public Health in Virginia—enrolls more than 1,900 undergraduate and 1,300 graduate students in its nationally recognized programs, including six undergraduate degrees, eight master’s degrees, five doctoral degrees, and six professional certificate programs. Comprising the School of Nursing and the Departments of Global and Community Health, Health Administration and Policy, Nutrition and Food Studies, and Social Work, the college also conducts transdisciplinary research that seeks to understand the many factors that influence the public health and well-being throughout the lifespan. With more than 500 partners, the college serves the community and engages its students through research, practice, and clinical care.

In This Story

Melissa J. Perry, Sc.D., MHS

Jenna Krall, PhD

Lance A. Liotta

Topics

public health research

Epidemiology

College of Science

College of Public Health

Press Releases

Lyme disease

Mason tapped by HRSA to lead health workforce initiatives in Virginia

Colleen Rich — Mon, 22 Apr 2024 17:09:32 +0000

Mason tapped by HRSA to lead health workforce initiatives in Virginia Colleen Rich Mon, 04/22/2024 - 13:09

As part of a federal priority to address health care workforce shortages, ��AV’s Center for Health Workforce has received $921,000 in federal funding from the Health Services Research Administration (HRSA) to serve as a catalyst and facilitator for regional health workforce planning and development.

Peterson Hall on Mason's Fairfax Campus. Photo by Evan Cantwell/Office of University Branding

The center uses data and a collaborative model involving health and educational organizations, policy makers, community planners, and other regional stakeholders to understand local challenges related to the supply, demand, distribution, and deployment of health workers in Virginia.

This funding was allocated in the Fiscal Year 2024 Labor, Health, and Human Services, Education, and Related Agencies appropriations bill, by Virginia Senators Mark Warner and Tim Kaine.

"Virginia urgently needs to expand its health workforce to meet community needs and ensure local businesses can supply essential health care services, and we appreciate the efforts of Senator Warner and Senator Kaine for moving our proposal through the Senate,” said Caroline Sutter, co-director of Mason’s Center for Health Workforce and a professor of nursing.

This strategic investment in Mason’s Center for Health Workforce will address this critical need to grow and retain the health workforce by prioritizing regional and population health recruitment and retention through evidence-based planning and targeted interventions. These targeted interventions will help regional educational and training programs identify future workers who want to stay in the area to give back and improve the region that trained them.

The new funds will help the center expand from supporting three GO Virginia regions to all nine GO Virginia regions. GO Virginia is a bipartisan, business-led economic development initiative focused on changing the way Virginia’s diverse regions collaborate on economic and workforce development activities.

"Virginia's health care system is grappling with both immediate workforce shortages and the imperative need for long-term strategic planning to build a sustainable workforce," said Sutter. "These shortages threaten to exacerbate existing health disparities and impede access to quality care in Viriginia.”

Nurses, physicians, allied health professionals, and support staff are in short supply due to increased demand from chronic staffing shortages, unfavorable or unsafe work environments, and unrelenting workloads, leading to overworked personnel and compromised patient care. Demand for health care is skyrocketing while the workforce is shrinking; in fact, 23% of physicians and at least 30% of nurses reported they would leave their jobs if they could and 50% of workers said they plan to leave their health care jobs in the next few years.

“Mason is stepping up as a leader to respond to the needs in health care workforce development in Virginia, setting a precedent for effective planning and collaboration across sub-state regions,” said Melissa J. Perry, dean of the College of Public Health.

Additionally, the center will support the development of employer-led public-private partnerships that can leverage private resources and address barriers in public needs.

“This funding will allow our teams to identify and increase bi-directional communication between employers and academic institutions or programs that train future health workers, so that future employees feel prepared and supported in their workplace, thereby retaining great talent,” said P.J. Maddox, center co-director and professor of health administration and policy at Mason.

The center has the only integrated data system in the commonwealth to help strategize with data-based decisions around health workforce recruitment and retention that employers and academic institutions can employ in each region. For example, the center has analyzed the supply and demand for today and in 10 years for behavioral health specialists for a specific region. With this information, regions can better target their recruitment and retention strategies to help keep the future workers they train in their area when they are ready to practice.

“As the first College of Public Health in Virginia and home to the highly ranked School of Nursing, Mason is bringing together education, research, and community partners for the health and well-being of all, everything that we do. We are grateful to Senators Warner and Kaine recognizing the impact the center has already had in three of Virginia’s regions and for supporting our efforts to further support our roles as an integral hub for additional health workforce centers and organizations seeking to increase health workforce across the commonwealth,” said Perry.

Because population health needs, economic conditions, and resources vary widely by region (rural, suburban, and urban), there is no one-size-fits-all set of strategies to address regional health workforce needs and population health priorities. More importantly, regional problem solving is necessary to develop strategies for improving education and career development to meet employer’s needs, expand supply, and improve retention.

In This Story

Melissa J. Perry, Sc.D., MHS

PJ Maddox, EdD, MSN, RN

Topics

Campus News

workforce

College of Public Health

Mary Cunningham

George Mason becomes new home for 400,000 biological specimens from Inova Health Systems

Uncover more research at the College of Public Health

In This Story

Related News

Topics

Songs from adolescence and early adulthood enhance mood and social engagement among people with dementia, according to new study

In This Story

Related Stories

Topics

College of Public Health receives NIH grant to pilot AI chatbot for African Americans with depression

In This Story

Topics

New research describes the leisure motivations that underpin young U.S. adults' recreational cannabis use

In This Story

Topics

George Mason researchers harness the power of artificial intelligence to match patients with the most effective antidepressant for their unique needs

In This Story

Discover more Research from the College of Public Health

Related News

Topics

Mason CARES intervention reduces stress and feelings of burden of family caregivers of older adults with dementia

In This Story

Topics

Should I be worried about bird flu? Everything you need to know

Should I be worried about bird flu right now?

Should we be worried that the current outbreak will spread?

Is milk safe to drink even though the virus has been found in milk?

In This Story

Topics

George Mason receives $1.2 million to revolutionize Lyme disease testing

Did you know...

Build your own research experience with ASSIP

Related News

Topics

����AV receives over $1.1 million to revolutionize Lyme disease testing

In This Story

Related Stories

Topics

Mason tapped by HRSA to lead health workforce initiatives in Virginia

In This Story

Related Stories

Topics

��AV receives over $1.1 million to revolutionize Lyme disease testing