CPH research

Interprofessional George Mason researchers awarded more than $1 million to improve outcomes for patients with depression

Jennifer Pocock — Tue, 10 Dec 2024 18:25:35 +0000

Interprofessional George Mason researchers awarded more than $1 million to improve outcomes for patients with depression Jennifer Pocock Tue, 12/10/2024 - 13:25

In This Story

Farrokh Alemi, PhD

Kevin Lybarger

Alison Evans Cuellar, PhD, MBA

Özlem Uzuner

Researchers Farrokh Alemi and Kevin Lybarger receive ��AV’s first Patient-Centered Outcomes Research Institute (PCORI) award to develop innovative Artificial Intelligence (AI) technology, including large language models, for improving antidepressant recommendations.

Farrokh Alemi and Kevin Lybarger

AI will soon receive a dose of empathy with the goal of helping to match people with depression to their best-fit medication. A team led by Farrokh Alemi, a professor in the College of Public Health (CPH), and Kevin Lybarger, an assistant professor in the College of Engineering and Computing (CEC), received $1,049,998 in research funding from the Patient-Centered Outcomes Research Institute (PCORI) to continue their work on developing an AI system that helps patients find the right depression medications.

With this funding support, Co-PIs Alemi and Lybarger will hone large language models (LLMs) to address known challenges in AI, including mitigating biases, reducing the potential for inaccurate information, and incorporating an empathetic tone, according to Alemi.

The new study will introduce an innovative way for AI to help patients make medication decisions. The AI system will engage patients in natural-language conversations to collect information about their medical history. The system will draw upon more than 10 million patient experiences with 15 different oral antidepressants and a National Institutes of Health All of Us database, which includes records from more than 80,000 participants with major depressive disorders, to help create a plan that is statistically likely to succeed. Alemi and Lybarger believe this will help alleviate the trial and error that can lead to negative patient outcomes.

The researchers will also introduce a first-of-its-kind patient simulator capable of mimicking various medical, linguistic, and behavioral characteristics. This simulator will be used to test and refine the AI system by simulating diverse patient scenarios, including infrequent but critical events such as suicidal ideation, to ensure the system’s recommendations are safe, culturally sensitive, and empathetic.

“This study was selected for its potential to address a high-priority methodological gap in patient-centered comparative clinical effectiveness research,” said PCORI Executive Director Nakela L. Cook. “We look forward to following the study’s progress and working with George Mason to share the results.”

This is the first PCORI-funded study that George Mason has received. “Depression is a major public health problem and we are excited to see the development of new AI-based decision tools, leveraging the multidisciplinary talents of our college to help tackle it,” said CPH Associate Dean of Research Alison Cuellar.

"This innovative study promises to generate methodologies for using AI for medical decision-support and for empowering patients to make critical health decisions beyond mental health,” says Özlem Uzuner, chair of CEC’s Department of Information Sciences and Technology.

This study is one of the latest funded by PCORI to examine which medical treatments work best, where and when treatment falls flat, and how to address the gaps. These studies deliver results that guide researchers in planning future studies and provide patients, their caregivers, and clinicians with the evidence-based information needed to make better-informed health and health care decisions.

Topics

grants

Depression

antidepressants

natural language processing

Artificial Intelligence

New study finds associations between use of skin care products and exposure to potential developmental toxicants

mthomp7 — Wed, 04 Sep 2024 13:15:40 +0000

New study finds associations between use of skin care products and exposure to potential developmental toxicants mthomp7 Wed, 09/04/2024 - 09:15

In This Story

Michael S. Bloom, PhD, MS, FACE

Use of skin care products is associated with exposure to phthalates and phthalate-replacement chemicals in young children, according to the new and first-of-its-kind study at ��AV's College of Public Health.

A new study led by primary investigator Michael S. Bloom, professor in the Department of Global and Community Health at George Mason’s College of Public Health, has found that use of skin care products including lotions, hair oils, hair conditioners, ointments, and sunscreen is associated with higher levels of phthalates in children’s urine. The associations depend in part upon the child’s racial and ethnic identity and their sex as assigned at birth. The study was co-authored by two George Mason Master of Public Health alumni, Juliana Clark and Kelly Garcia.

A new study led by primary investigator Michael S. Bloom has found that use of skin care products including lotions, hair oils, hair conditioners, ointments, and sunscreen is associated with higher levels of phthalates in children’s urine. Photo by Michelle Thompson/College of Public Health

“This is the first study to suggest that different skin care products used by young children may differentially increase exposure to endocrine-disrupting phthalates and phthalate replacements in young children,” said Bloom.

Phthalates and phthalate-replacement compounds are endocrine-disrupting chemicals, meaning they may interfere with the body’s hormones. Exposure to these chemicals in early childhood has been associated with neurodevelopmental, reproductive, and metabolic disease concerns in previous studies. Some of these chemicals are often used as carriers for the active ingredients in skin care products; others may be used in plastic packaging.

The study collected medical data from 630 children between the ages of 4 and 8 from 10 different sites across the United States, including a clinical examination and a urinalysis. The child’s parent or guardian was also asked to complete a survey within 24 hours prior to the child’s examination, which included questions regarding the child’s sociodemographic information (race/ethnic identity, sex assigned at birth, etc.). It also asked parents to list all the skin care products, including lotions, soaps, shampoos, oils, and cosmetics, that were applied to the child’s skin in the 24 hours prior to their examination, with as much specificity as possible regarding the product type and brand or generic name.

“We found associations between recent use of different skin care products and higher concentrations of phthalate and phthalate-replacement compounds,” said Bloom. “There were different relationships between the use of skin care products and the endocrine-disrupting chemicals in children depending on their racial and ethnic identities and their sex assigned at birth. We also found that distinct patterns of using multiple skin care products were predictive of higher concentrations of phthalates and phthalate replacements.”

While Bloom and his team say that further studies are necessary to confirm these findings, the results suggest that children in different racial and ethnic groups may experience different levels of risk for exposure to phthalates. In particular, they found the highest levels of phthalates and phthalate replacements in the urine of non-Hispanic Black participants. The differences may correlate to brand availability and preferences, methods and timing of product application, and/or the frequency of use by children with different racial and ethnic identities.

“The results can inform policies to address the use of endocrine-disrupting chemicals in skin care products that may be used on children and to help advise parents’ decisions about using products to limit their children’s exposure to potential developmental toxicants,” said Bloom.

“Impact of skin care products on phthalates and phthalate replacements in children: the ECHO-FGS” was published online in Environmental Health Perspectives in September 2024. This research was funded by the U.S. National Institute of Health (NIH) Environmental Influences on Child Health Outcomes (ECHO) study.

Additional authors include: Juliana Clark, ��AV; John L. Pearce, Medical University of South Carolina; Pamela L. Ferguson, Medical University of South Carolina; Roger B. Newman, Medical University of South Carolina; James R. Roberts, Medical University of South Carolina; William A. Grobman, The Ohio State University Wexner Medical Center; Anthony C. Sciscione, Christiana Care Health System; Daniel W. Skupski, New York Presbyterian Queens Hospital; Kelly E. Garcia, ��AV; John E. Vena, Medical University of South Carolina; Kelly J. Hunt, Medical University of South Carolina; the ECHO-FGS study group.

Topics

Master of Public Health

Environmental Chemicals

Research

Online learning expert suggests best practices for promoting academic honesty

Jennifer Pocock — Tue, 13 Aug 2024 17:44:33 +0000

Online learning expert suggests best practices for promoting academic honesty Jennifer Pocock Tue, 08/13/2024 - 13:44

In This Story

John Cantiello, PhD

The growing popularity of easy-to-use artificial intelligence (AI) interfaces has reignited discussions about cheating in academics. Academic dishonesty, however, is a long-standing concern for faculty and a burgeoning area of research for online coursework. Whether cheating is more or less prevalent in remote coursework has been the topic of debate since online coursework went mainstream in the early 2000s. While online learning provides access to education for nontraditional students and in nontraditional circumstances (such as the COVID-19 pandemic), it’s important to ensure that students are authentically learning the material.

John Cantiello. Photo provided

To understand the prevalence of cheating and help teachers address it, John Cantiello, a professor of the Department of Health Administration and Policy, reviewed the existing literature on the topic. In the Journal of Health Administration Education, Cantiello, who was honored last year as an online teacher of distinction by the Stearns Center of Teaching and Learning, reports that many methods for preventing academic dishonesty are effective.

Not everyone agrees on what constitutes “dishonesty,” he points out. While some forms of cheating are clear-cut—having others do assignments or take tests in the place of the student, plagiarism, or copying answers, others are not. Up for debate are the use of tools like artificial intelligence, or consulting publications that, in a professional setting, would be available to them while solving problems.

“This paper illustrates varying results on the frequency of cheating in online, college-level courses,” Cantiello said. “Tools and strategies for preventing academic dishonesty vary in effectiveness, but some show significant success.”

Cantiello examined many different interventions to prevent online academic dishonesty, including frequent discussions on what constitutes cheating and plagiarism (e.g., can they use AI tools in this course?), technology (e.g., biometric hardware and software such as Turnitin or Examity), and varied testing strategies (e.g., limiting testing times, multiple versions of tests, and leaking fake answers online).

He suggests that a combination of strategies is the best way to limit cheating. “A holistic approach to course design that incorporates these elements and includes a variety of learning activities fosters an effective learning environment where academic integrity can be upheld,” Cantiello said. However, he says, more research is needed on how often and in what capacity cheating happens.

“Preventing Academic Dishonesty in Online Courses: Best Practices to Discourage Cheating” was published online in March 2024 in the Journal of Health Administration Education. Renee Hotchkiss Geschke is co-author on the paper.

Topics

College of Public Health

Artificial Intelligence

George Mason becomes new home for 400,000 biological specimens from Inova Health Systems

Mary Cunningham — Wed, 17 Jul 2024 00:07:11 +0000

George Mason becomes new home for 400,000 biological specimens from Inova Health Systems Mary Cunningham Tue, 07/16/2024 - 20:07

��AV’s College of Public Health is the new home of 400,000 biological specimens through a partnership with Inova Health Systems. This repository of specimens, called a biobank, is an extensive collection of obstetrical and perinatal samples, along with follow-up health information, providing a rare and invaluable asset in public health and in the education of our future health, science, and technology care workforce.

“The biorepository creates opportunities for Mason to expand its collaborations with Inova, biotechnology partners, and other universities in Virginia, as well as unique educational opportunities,” said Melissa Perry, dean of the college.

Larry Maxwell, president of the Women’s Service Line at Inova Health System, said, “The investment by Inova Health System as well as additional support from the Fairfax County Government have created an unprecedented resource of placenta as well as blood specimens from mother, father, and baby [trios] corresponding to over 4,000 families. These biospecimens and corresponding data continue to support scientific research to better understand the obstetrical diseases that contribute to rising rates of maternal morbidity and mortality locally, regionally, and nationally.”

A range of specimens (e.g., saliva, urine, and blood) were collected with consent from an Inova cohort study that followed more than 4,000 women, their partners, and their children from pregnancy into early childhood to examine maternal health, pregnancy outcomes, and children’s growth and development.

Biobank program leads Carolyn Drews-Botsch and Michael S. Bloom. Photo by Evan Cantwell/Office of University Branding

“The transfer of the biobank from Inova Health System to the College of Public Health serves as a testament to our strong public–private partnership, and underscores George Mason’s dedication to advancing health in pregnancy and early childhood,” said Alison Cuellar, College of Public Health associate dean for research. The biobank is housed at the university’s Science and Technology Campus in Manassas, Virginia.

The biobank offers an unprecedented opportunity for George Mason researchers to engage with and involve Virginia’s undergraduate and graduate students in health and public health science, to expand Virginia’s health, science, and technology workforce pipeline and enhance its diversity.

“The availability of such comprehensive and diverse datasets within a single biobank is rare, making it an attractive asset for collaboration and groundbreaking research endeavors,” said Michael S. Bloom, program lead of the College of Public Health Biobank and George Mason professor.

Space at the SciTech Campus for the biobank was renovated to hold the 11 tanks (called dewars) and freezers full of specimens. Photo by Evan Cantwell/Office of University Branding

Bloom and co-lead Carolyn Drews-Botsch started the work for the biobank transfer in 2021. Inova chose Bloom and Drews-Botsch after extensive vetting of their prior research experience, including involvement in large cohort studies, such as those from which these specimens are drawn. Space at the SciTech Campus for the biobank was renovated to hold the 11 tanks (called dewars) and freezers full of specimens. The containers are kept between -80 degrees C and -190 degrees C to maintain specimen integrity during long-term storage.

“These specimens will be vital for public health researchers who are looking to identify associations and factors that support healthy pregnancy and child health and ultimately benefit the public’s health,” said Drews-Botsch, a professor in the College of Public Health.

The professors expect the biobank to become a leading resource for collaborative projects once a research database is developed, with other researchers analyzing the data to answer important public health questions.

“By actively fostering these partnerships, George Mason can position itself as a leader in research around maternal health and early childhood and contribute to the advancement of public health on a larger scale,” Perry said.

Uncover more research at the College of Public Health

In This Story

Michael S. Bloom, PhD, MS, FACE

Carolyn Drews-Botsch, PhD, MPH

Alison Evans Cuellar, PhD, MBA

Melissa J. Perry, Sc.D., MHS

Topics

Maternal Child Health

Science and Technology Campus

Songs from adolescence and early adulthood enhance mood and social engagement among people with dementia, according to new study

Mary Cunningham — Mon, 24 Jun 2024 21:18:46 +0000

Songs from adolescence and early adulthood enhance mood and social engagement among people with dementia, according to new study Mary Cunningham Mon, 06/24/2024 - 17:18

Around 46% of residents in U.S. nursing homes have Alzheimer's or other dementias, and 13% of them are treated with antipsychotic medications, according to the National Partnership to Improve Dementia Care in Nursing Homes.

Photo by Getty Images

Antipsychotic medications that affect a person’s mental state have been widely prescribed for people living with dementia in nursing facilities to treat their behavioral (social) and psychological (mood) symptoms, though positive results are limited, and the drugs can come with serious side effects. ��AV College of Public Health faculty are part of a growing group of researchers who are seeking therapeutic ways to improve the quality of life of these residents without medication.

New research, led by principal investigator Megumi Inoue, found that personalized music intervention is effective at reducing the use of antipsychotic and antianxiety medication, alleviating agitation levels, and enhancing mood and social engagement among residents.

Personalized playlists were developed based on family member suggestions regarding what songs, artists, and/or genres the participants listened to when they were around 15 to 25 years old, an age when more memories are available for potential recollection. Facility staff played the personalized playlists for the intervention group twice a week, aiming for at least 30 minutes each session, for four weeks. Participants in the control group continued their usual schedule during these four weeks.

Associate Professor of Social Work Megumi Inoue

“This study provides evidence that personalized music intervention can be used to manage distressing behavioral and psychological symptoms associated with dementia,” said Inoue, an associate professor in the Department of Social Work. "This low-cost, easily implementable intervention, requiring no special licensure for administration, can significantly enhance the quality of life for nursing facility residents

Overall, the intervention group experienced a decrease in average antipsychotic medication use after the intervention, and the control group, which did not receive any music, had an increase in medication use during the same time period. The observational data also revealed that this intervention can improve the mood of residents living with dementia and help them connect with others, while surveys from administrative staff and activity directors highlighted their positive views of the intervention.

“In addition to improving patients’ quality of life, this intervention can create an improved environment throughout the nursing home,” said Inoue. "For example, if personalized music helps reduce residents’ challenging symptoms, they will become easier to work with for direct care workers. In addition, the reduction of medications to treat residents’ psychological and behavioral symptoms will contribute to creating an overall safer facility because such medications have sedating effects that can cause falls."

She added, "Using the personalized music intervention may be perceived as extra work by some staff members, but ultimately, it can ease their work processes as its positive effects have indirect impacts on their work and facility environment."

“A Personalized Music Intervention in Nursing Home Residents Living With Dementia: Findings From a Randomized Study” was published online in the Journal for Applied Gerontology in June 2024. This research was supported by a Civil Money Penalty (CMP) Fund from the Centers for Medicare and Medicaid Services through the Virginia Department of Medical Assistance Services.

Additional authors include Emily S. Ihara, Catherine J. Tompkins, Shannon Layman, Sarah Nosrat, Morgan Moore, and Kimberly A. McNally from George Mason’s College of Public Health; Meng-Hao Li from George Mason’s Schar School of Policy and Government; Samreen Mehak from George Mason’s Department of Biology; George Mason alumna Kendall Barrett from Wise Mind Psychotherapy; and Catherine Magee from Paving the Way MSI.

In This Story

Megumi Inoue, PhD

College of Public Health receives NIH grant to pilot AI chatbot for African Americans with depression

Mary Cunningham — Mon, 10 Jun 2024 17:03:05 +0000

College of Public Health receives NIH grant to pilot AI chatbot for African Americans with depression Mary Cunningham Mon, 06/10/2024 - 13:03

In This Story

Farrokh Alemi, PhD

Janusz Wojtusiak, PhD

Kevin Lybarger

As a leader in innovative health solutions, ��AV’s College of Public Health received a National Institutes of Health (NIH) AIM-AHEAD program grant to pilot an artificial intelligence (AI) chatbot for Black and African Americans with depression. Professor Farrokh Alemi will enhance his first-of-its-kind, evidence-based artificial intelligence tool to address the medication needs of African Americans with depression.

Professor of Health Informatics Farrokh Alemi

The existing AI tool recommends antidepressants for 16,775 general-population patient subgroups, each representing a unique combination of medical history. For each of these subgroups, the current project will analyze the effectiveness and appropriateness of the recommendations for African Americans, using the NIH All of Us database and existing published literature.

To the researchers' knowledge, this is the first research focused on developing and evaluating an antidepressant recommendation system for Black and African American people.

“Antidepressant medications are a first-line treatment for depression; however, a majority of depressed patients do not experience improvement with their first antidepressant. Additionally, minority populations, including Black and African Americans, are not well represented in antidepressant studies, contributing to reduced antidepressant effectiveness in these populations,” said Alemi. “There is a significant need to synthesize available evidence regarding antidepressant effectiveness and provide personalized treatment recommendations, and this project addresses a major gap in the management of Black and African Americans with depression.”

Researchers will develop a Knowledge-enhanced Antidepressant Recommendation Dialogue System (KARDS), which will engage users in a back-and-forth conversation to acquire the patient information needed to identify the appropriate antidepressant medication. The AI will provide the patient with a list of recommended medications, list of the relevant studies, and an explanation for the medication decisions. The system will automatically send the patient’s clinician a brief point-of-care recommendation and explanation, with an option to examine a complete record of the conversation and the supporting evidence.

“Chatbots—or patient-facing dialogue systems like the one we will create—hold transformative potential for the health care sector and are increasingly prominent in psychiatric applications, predominantly through therapy-bot implementations,” said Alemi. “Our chatbot will help improve the detailed, time-consuming, medical history intake process, and provide point-of-care summary and prescription recommendations to the patients’ clinicians. The chatbot will make patients more comfortable because the natural language modality provides an intuitive, empathetic, stigma-free interface.”

Once the AI chatbot is developed, the team will test the dialogue system with Black and African American patients to evaluate system functionality and user preferences. Additionally, the project will train a Black or African American doctoral or master’s student in AI, expanding the available workforce and building the community’s capacity to address AI.

Alemi will lead the research team, which includes Janusz Wojtusiak, a George Mason professor of Health Informatics and the director of the Machine Learning and Inference Laboratory, and Kevin Lybarger, a George Mason assistant professor in the Department of Information Sciences and Technology in the College of Engineering and Computing. All three members have collaborated previously to diagnose COVID at home from presenting symptoms.

The $70,906 grant is part of the NIH’s AIM-AHEAD (Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity) program, which aims “to establish mutually beneficial and coordinated partnerships to increase the participation and representation of researchers and communities currently underrepresented in the development of AI/machine learning models and enhance the capabilities of this emerging technology, beginning with electronic health record data.”

Innovate for Good is an ongoing series that examines how George Mason faculty in the College of Public Health are harnessing technology to improve health outcomes.

If you have stories to share as part of the Innovate for Good series, email Mary Cunningham at mcunni7@gmu.edu.

Topics

Artifical Intelligence

Tech Talent Investment Program (TTIP)

New research describes the leisure motivations that underpin young U.S. adults' recreational cannabis use

Mary Cunningham — Mon, 10 Jun 2024 15:40:21 +0000

New research describes the leisure motivations that underpin young U.S. adults' recreational cannabis use Mary Cunningham Mon, 06/10/2024 - 11:40

In This Story

Iulia Fratila, PhD

As of 2024, 24 states including Virginia, Maryland, and Washington, D.C., have legalized the adult recreational use of cannabis. As laws change, citizens' perceptions of the drug and reasons for using the drug have also shifted. In 2020, 34.5% of adults aged 18–25 reported using cannabis in the previous 12 months, according to the Substance Abuse and Mental Health Services Administration. Health experts seek to better understand the broader implications of legalization and individuals’ motivations and attitudes related to cannabis use.

Iulia Fratila, assistant professor in ��AV’s College of Public Health

New qualitative research by Iulia Fratila, assistant professor in ��AV’s College of Public Health, and Liza Berdychevsky, associate professor at the University of Illinois Urbana–Champaign, describes in what ways young adults (aged 18–30) view cannabis as a recreational and leisure pursuit.

“Recreational cannabis legalization and liberalization is shifting across U.S. states. More holistic approaches to understanding perceptions of cannabis benefits and leisure motivations are scarce due to the longstanding criminalization of cannabis,” said Fratila, the principal investigator. “This research provides novel insights into cannabis users' leisure motivations of use and perceived benefits, which can be leveraged strategically in public health and drug education efforts in the societal transition from criminalization to normalization and commercialization trends concerning cannabis.”

Participants in Fratila and Berdychevsky’s study suggest cannabis can offer a leisure state of mind (e.g., experiencing flow, relaxation, and meditative state), as well as represent a leisure pursuit reserved for free time (e.g., using cannabis as a reward for free, post-obligations time outside of daily demands). Additionally, participants described how cannabis serves as a leisure activity itself (i.e., the act of getting high) and/or as an activity that accompanies other leisure pursuits and socialization (e.g., getting high and going to the movies), while providing pleasurable outcomes (e.g., feeling enjoyment, engaging in humor, enhancing senses).

“Participants discussed the ways that their recreational cannabis consumption represents a controlled and calculated risk-benefit leisure choice that is successfully managed for their overall well-being. Their narratives highlight that this perceived leisure pursuit does not necessarily interfere with their otherwise productive lives,” said Fratila.

These insights can inform harm reduction approaches to cannabis education that may be more effective considering the cannabis legalization and liberalization landscape. Health educators and health promoters can discuss cannabis risks and potential negative health outcomes while acknowledging the desired benefits cannabis users anticipate.

Fratila warns about the impacts of widespread legalization and the emerging recreational cannabis markets, which highlights another meaningful implication connected to the study findings. “Under prohibitory regulations, recreational cannabis use has been explicitly framed as deviant, criminal, harmful, life-wrecking, and void of any potentially desirable leisure qualities (e.g., pleasure, socialization). This study showcases the cannabis users’ understanding of cannabis as normative recreation and the anticipated leisure benefits,” said Fratila.

She further explained, “However, this is a cautionary tale because these desirable qualities may be easily exploited. More specifically, society may be facing a new conundrum with the commercialization of recreational cannabis as the switch from criminalization to commercialization overly simplifies and glamorizes the leisure meanings of cannabis for profitable gain.”

Public health experts and scholars will need to be at the front lines, in collaboration with other fields, to monitor how cannabis is repositioned and accommodated in a cannabis-friendly society, according to Fratila. Specifically, it will be important to spearhead effective health promotion efforts that minimize any related harms and maximize well-being.

This was a qualitative research project utilizing hermeneutic phenomenology, a research method to study how experiences affect everyday practices, and in-depth interviewing with 16 individuals (ages 18–30) living in the U.S. states with legalized recreational cannabis.

“Phenomenological Exploration of Young Adults’ Recreational Cannabis Use Experiences and Associated Leisure Meanings” was published in the Journal of Leisure Research in June 2024. This research was not funded.

Topics

George Mason researchers receive $1.78M from NIH for work improving the health of mothers, children

Shayla Brown — Wed, 05 Jun 2024 16:57:43 +0000

George Mason researchers receive $1.78M from NIH for work improving the health of mothers, children Shayla Brown Wed, 06/05/2024 - 12:57

��AV scientists, nurses, and researchers in the College of Public Health have just entered the second cycle of a National Institutes of Health (NIH) program called Environmental influences on Child Health Outcomes (ECHO).

The NIH grant provides ECHO teams across the country with a total of $7 million a year for seven years to research five outcomes of women and children: pre-, peri-, and postnatal outcomes; upper and lower airways; obesity; neurodevelopment; and positive health. George Mason will receive $1.78 million every year throughout this cycle.

An ECHO researcher taking measurements of a child participant. Photo by Evan Cantwell/Office of University Branding.

The cohort, which includes Boston Children’s Hospital, is led by the Icahn School of Medicine at Mount Sinai. George Mason is the only university in Virginia participating in the project. The research being done for the ECHO project is part of a new set of research initiatives made possible with the opening of the Population Health Center on the Fairfax Campus.

They are currently re-recruiting participants from the first cycle. They have confirmed just over 300 participants out of 1,512. The youngest participant is under one year old and the oldest is 12.

“We’re aiming to gather information about women and children in a longitudinal manner to compare to our data to that of Omaha, Nebraska, or Iowa. Learning about the regional disparities will then allow us to use them to influence national policy,” said principal investigator Kathi Huddleston, PhD ’08, an associate professor in the College of Public Health.

Huddleston said George Mason’s robust PhD nursing program and her dissertation research on pediatric emergency preparedness helped to prepare her for this extensive project.

The team studied the effects of per- and polyfluoroalkyl substances (PFAS), also known as “forever” chemicals, as well as air pollution modeling, sleep patterns, nutrition, and COVID-19, gathering real-time data and look at their associations with child health outcomes, such as child obesity, immunization rates and more.

This research from the first cycle of ECHO revealed that school lunch consumption was associated with increased obesity in children and prompted policy change that strengthen the Healthy, Hunger-Free Kids Act (HHFKA). This resulted in a significant decrease in the overall body mass index among school-aged youths and will have substantial health benefits on generations of children.

More results from the first cycle included changes in sleep patterns due to COVID-19 and disparities in sleep patterns between children of different racial/ethnic backgrounds. The team also found that there is a strong relationship between the health of the mother at pre- and early conception and the overall health of children. For example, babies born to mothers with higher levels of toxic metals were more likely to be underweight, which could lead to future health issues.

“If we want to have healthy kids, we have to have healthy moms,” said Huddleston.

As part of cycle two, the researchers will recruit more pregnant women to gain additional insight, including women who were patients at Inova Health System and have also been working with a lot of the same kids for many years, said Grace Lawrence, PhD ’18, director of research clinical operations for the ECHO project.

Student researchers Daisy Posada, Seema Poudel, and Shiva Zarean. Photo by Evan Cantwell/Office of University Branding.

Also on the team are Alma Fuller, nursing student Shiva Zarean, and research project administrators Daisy Posada BA ’13, MA ’18, and Bruna Mayen, a biology major who also acts as the project and lab manager. Mayen’s role as lab manager includes collecting teeth, hair, and urine samples to test the progression of health and well-being in the participants as they grow.

“I ensure samples are stored at required optimal conditions and freezers are monitored daily,” said Mayen. “I also perform data entry and quality assurance/quality control of all data and samples.”

“Each interaction with the participants is so special, it brings potential for new connections and enriches the overall experience and impact they have on the study and us on their development,” said Mayen.

The families come into the research facility once a year so researchers can record each family member’s weight, height, and head and waist circumferences, as well as their body fat percentage.

“We were in the ECHO study when my first child was a newborn. Then my second child was born, and we just kept going,” said Cassie Gallagher, a mom of three young children, all of who participate in the ECHO study. “We’ve been very active in the study, we send in nails, teeth, everything.”

“I also appreciate how thorough the questions are in the surveys that they send us because they’re trying to get the important answers. Especially when they ask about our stress level and different environmental aspects,” said Gallagher.

The project encompasses the concept of citizen science as the participants provide all of the information being used to create an impact in public health. They also receive quarterly updates with the researchers’ findings.

“One of the understated benefits of this study is that children are encouraged to participate firsthand in science and gather an understanding of science in a very personal way,” said Huddleston. “We have received wonderful feedback from the kids about how they feel giving new information to better all children’s health.”

In This Story

Dr. Kathi Huddleston, PhD, MSN

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Mason CARES intervention reduces stress and feelings of burden of family caregivers of older adults with dementia

Mary Cunningham — Wed, 29 May 2024 15:50:53 +0000

Mason CARES intervention reduces stress and feelings of burden of family caregivers of older adults with dementia Mary Cunningham Wed, 05/29/2024 - 11:50

In This Story

Dr. Cathy Tompkins

Gilbert Gimm, PhD

According to the U.S. Centers for Disease Control and Prevention, 80% of those living with dementia receive informal care from family members or friends. This equates to 16 million family caregivers in the U.S. However, caring for family members with dementia is often associated with increased caregiver burden (which includes emotional, physical, and financial strain), stress, and worse physical health for the caregiver.

Catherine Tompkins, principal investigator, professor of social work, and associate dean of faculty and staff affairs in the College of Public Health.

A recent study published in the Journal of Applied Gerontology, led by ��AV researchers, found that a 9-week online stress management intervention program for family caregivers reduced burden scores by 15% for 97 family caregivers of older adults living with dementia. The Stress-Busting Program for Family Caregivers TM, intervention was specifically designed to help family caregivers manage their own stress when caring for older adults living with dementia or a chronic illness

“In this study, we found evidence of a range in average caregiver burden levels based on the dementia severity category of care recipients. The findings show that an online Zoom intervention in a peer group setting can be beneficial for family caregivers of older adults with mild, moderate, or severe dementia,” said Catherine Tompkins, principal investigator, professor of social work, and associate dean of faculty and staff affairs in the College of Public Health.

The intervention provided family caregivers with education and strategies to manage stress when caring for someone living with dementia. Examples of self-care techniques included breathing and meditation; troubleshooting behaviors associated with dementia; and peer-to-peer support within a virtual group setting.

Associate Professor Gilbert Gimm

“Reducing caregiver burden and managing stress are critical to the well-being of families. These findings show that effective stress management interventions for family caregivers can be facilitated through online peer groups,” said Gilbert Gimm, first author and associate professor of health administration and policy.

“Mason Caregivers Aiming for Resilience, Empowerment, and Support Study: Assessing Family Caregiver Burden Post-Intervention” was published online in April 2024. Co-authors include George Mason Associate Professor Megumi Inoue, Professor Emily Ihara, Mason CARES Project Manager Shannon Layman, and Master of Social Work alumna graduate Harveen Pantleay. This study was supported by a grant (#2021048) from the Retirement Research Foundation (RRF).

The study is part of a larger project, entitled Mason CARES (Caregivers Aiming for Resilience, Empowerment, and Support), that implemented and assessed interventions for family caregivers.

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Ageism research helped prepare these social work grads for the workforce

Shayla Brown — Tue, 21 May 2024 20:42:16 +0000

Ageism research helped prepare these social work grads for the workforce Shayla Brown Tue, 05/21/2024 - 16:42

In This Story

Emily Ihara, PhD, MSW, FGSA

While working on their master’s degrees in social work at ��AV, College of Public Health alumni Kendall Barrett, Madeline Holden, and Harveen Pantleay took part in field research on ageism in health care and are now using those skills in their careers.

They are also co-authors on the paper “’Don’t treat us like fragile babies:’ Mentors’ perspectives of an intergenerational mentoring program for medical students,” which was published online in the Journal of Intergenerational Relationships in February 2024.

��AV is a leader in graduating workforce-ready students, and its College of Public Health—the first in Virginia—is dedicated to helping meet the critical need for health workers in Virginia.

Kendall Barrett. Photo provided.

The three, working under the guidance of Emily Ihara, professor and chair of the Department of Social Work, and co-PI of George Mason’s Geriatrics Workforce Enhancement Program, studied the effects of ageism in health care and how both education and intergenerational contact can decrease this form of discrimination. As the students learned, the research improves empathy and understanding from both younger and older individuals within the health care system.

For the study, the students went to assisted living facilities to interview residents using open-ended questions and took detailed notes.

“This was a very important research project to me because there was a lot of focus on alternative and creative ways to support older people, which is a particular interest of mine,” said Barrett, MSW ’22, who was paired with Ihara as a student research assistant at George Mason’s Social Work integrated Research Lab (SWiRL).

“It was very interactive, and we were trying to show that we heard them and that their contribution was important,” said Barrett, who is now works as a psychotherapist with people of all ages.

Harveen Pantleay. Photo provided.

“I was really nervous in the beginning because we were going into somebody's private space and didn't always know what [to expect], but it ended up being a wonderful experience and great for my own personal growth about sitting with things that can be uncomfortable,” said Barrett.

Both the George Mason students and the older adults benefitted from the Senior Mentor Program approach, and Ihara said the college hopes to expand it to other health professional students.

“One of the biggest things that I took away from my time in George Mason’s social work program was seeing people as individuals before you see whatever their struggle is,” said Barrett.

Pantleay, MSW ’22, also worked alongside Barrett and Ihara in SWiRL and was involved in many projects specifically focusing on gerontology.

“I gained a lot of valuable knowledge about qualitative data and how to classify that data into categories [through] analyzing the data and identifying what codes would be associated with the responses that were given by the mentors and participants,” said Pantleay.

Pantleay’s favorite part about the research project was learning about gerontology as it was a part of social work that she did not have much experience in at the time, she said.

Madeline Holden. Photo provided.

“A lot of what I learned through the work and research in SWiRL wasn't covered in my classes necessarily, so this experience allowed me to learn a lot more about this community and the negative effects of ageism in health care,” said Holden, MSW ’22.

“I think the main takeaway from the research is that people make a lot of assumptions about older adults that they shouldn’t,” said Holden, who also conducted clinical research for Inova Hospital for three years before enrolling for her master’s of social work at George Mason.

Holden said now uses her experience from this project in her work at an affordable housing corporation. “I work with all ages, including seniors, providing wraparound services to them. The empathy and understanding the team had for their participants throughout this project was great practice for that.”

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College of Public Health

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Department of Social Work

Research

Healthcare Workforce Development

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master of social work

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