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This George Mason alum can help you sleep better

Colleen Rich — Thu, 26 Sep 2024 16:16:30 +0000

This George Mason alum can help you sleep better Colleen Rich Thu, 09/26/2024 - 12:16

In high school and as an undergraduate student, Dan Gartenberg, MA Psychology ’12, PhD ’16, would stay up late and struggle to wake early, a typical experience for many students. Early on in his graduate studies at ��AV, he took a course on the neuroscience of sleep and was hooked.

Dan Gartenberg. Photo provided

Gartenberg became passionate about the study of sleep, due to his own personal struggles with sleep—including delayed sleep phase syndrome and insomnia. He is now founder and CEO of SleepSpace and a scientific advisor to other companies in the sleep science field, including Wesper, Biostrap, CPAP.com, Perfectly Snug, and MDBiowellness.

“Mason is where I learned to be a scientist, constantly question things, and where I learned the scientific method. That’s an invaluable thing,” he said.

For his dissertation in psychology, Gartenberg worked with the Naval Research Laboratory to develop artificial intelligence (AI) models that could help predict when people, such as pilots, are getting fatigued doing a task for a long period of time by using eye tracking data.

“I was making models of fatigue and using different cognitive tasks to predict when errors would occur,” he said. “You don’t want a pilot to crash a $30 million aircraft, and there are ways to tell when someone is tired based on their [movements].”

Gartenberg published several papers and released his first few sleep apps around this time. He worked closely with the late George Mason professor Raja Parasuraman, an expert in the field who developed one of the main theories of vigilance.

Photo provided

While at George Mason, Gartenberg received grants from the National Science Foundation to test whether playing certain sounds during sleep could encourage deeper sleep. His research team brought people into a lab and hooked them up to polysomnography—like an EEG but used to measure multiple physiological data streams.

They played sounds on the up state of delta brainwaves and showed some evidence that it primes deeper sleep. Gartenberg and his colleagues went on to get more grant funding in that area. But he found having someone wear a device was cumbersome.

“And it wasn’t a great form factor for consumers, so I pivoted a bit toward insomnia,” he said.

Then, in 2020, he received a $2.5 million grant from National Institutes of Health to develop a new digital therapeutic for insomnia. He recently ran a randomized control trial to test this novel therapy. This is the main focus of his company, SleepSpace. He also raised $1.8 million from venture capitalists to build this sleep improvement platform.

First, Gartenberg and team created very accurate sleep trackers. Gartenberg made some algorithms on the Apple watch and using smartphone sensors to track sleep in real time for the purpose of playing sounds to augment sleep and later integrated smart lights.

Gartenberg said that cognitive behavioral therapy (CBT) is the treatment for insomnia recommended by the American Academy of Sleep Medicine and other academies. So the team built a six-week CBT course with collaborators at Penn State University and the University of Arizona. The software also integrates with sound and light devices to promote improve sleep quality, and includes meditations and interactive content driven by an AI chatbot called Dr. Snooze.

“Our software allows the coach or a sleep doctor to see their client’s data from the app and wearable devices, so they can see the perception of sleep alongside what’s happening and create customized sleep programs,” he said.

Gartenberg and colleagues showed that when people experience the treatment as usual plus the software, more people were able to avoid insomnia remission, and it was more effective at treating it on some metrics. Since launching, they have 30 therapists and coaches using the platform and have seen more than 100,000 downloads.

“We’re augmenting the therapist, not replacing them,” Gartenberg emphasized.

He’s currently working on developing a comprehensive package to improve sleep and also launching a new smart topper and bedsheet called the SleepSpace Smart Sheet that will integrate with his current software and be able to control the temperature on either side of the bed. It can help with falling asleep, hot flashes, night sweats, and navigating different temperature needs of partners.

And it all started at George Mason. Gartenberg said the university played a major role in his career as a scientist and entrepreneur.

“George Mason gave me, as a PhD, the freedom to pursue a lot of different interests that weren’t strictly in one field,” he said. “It was a combination of software development, science, and even intellectual property. I worked with Mason’s [Tech Transfer] team on some patents, and I got my first patent granted through that collaboration.”

Gartenberg’s advice for Mason students is to know who you are and what you want. He took the entrepreneur route, but he admits it’s not for everyone, and it can be quite stressful. However, he thinks entrepreneur skills are more important than ever, especially creative problem solving and persistence.

“If you can creatively solve problems, that can be applied to almost anything.”

Learn more about Gartenberg's work

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College of Humanities and Social Sciences

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National Institutes of Health

Mason named to top 100 list for patents awarded in 2022

Colleen Rich — Thu, 12 Oct 2023 13:30:11 +0000

Mason named to top 100 list for patents awarded in 2022 Colleen Rich Thu, 10/12/2023 - 09:30

It isn’t surprising that ��AV, a university that has been recognized for its innovation and entrepreneurship, would be among the top 100 universities in United States for patents. This fall, the National Academy of Inventors ranked Mason No. 91 in its list of the top 100 universities granted patents during 2022.

Photo by Evan Cantwell/Office of University Branding

“Mason is in the business of discovery,” said Andre Marshall, vice president for research, innovation, and economic impact. “Our researchers are curiosity-driven. As such, we don't always know where our research will lead or what impact it may have. I am absolutely delighted that the Mason Enterprise tech transfer team is working with our researchers on inventions and patents to transform our discoveries into impact.”

In 2022, the U.S. Patent and Trademark Office issued 15 utility patents to Mason inventors including a method to monitor physical cues for people in recovery, a wearable device for knee injuries, a system for detecting power grid states and determining appropriate actions, and therapeutics for dealing with human immunodeficiency virus (HIV), to name a few. Utility patents cover the creation of a new or improved—and useful—product, process, or machine.

Mason professors Padmanabhan Seshaiyer of the Department of Mathematical Sciences and Holly Matto, Department of Social Work, share a patent for systems and methods for biobehavioral-regulation treatments. Their invention provides recovery support for users by monitoring their biobehavioral state and strategically delivers, in real time, personalized recovery cues to treat and prevent relapse. It is the first patent for the Department of Social Work.

Researchers Marissa Howard and Lance Liotta at Mason’s Center for Applied Proteomics and Molecular Medicine patented a wearable device that measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. The device collects metrics, such as temperature, patellar shifting, limb circumference, and acceleration, and communicates them through a networked communication system so medical personnel and patients can stay updated with the patient’s rehabilitation progress and make adjustments.

Mason alum Eniye Tebekaemi, PhD Information Technology ’18, and Duminda Wijesekera of the College of Engineering and Computing were awarded a patent for a secure overlay communication model for decentralized autonomous power grids. The model is a logic-based system deployed onto computing devices in power grid stations and substations. In response to detecting various power grid faults, such as line failures and over-current states, the system can automatically rearrange power line configurations.

Researcher Yuntao Wu, a professor in Mason’s School of Systems Biology and the Center for Infectious Disease Research, was awarded two patents in 2022 for his work on HIV: “Targeting the Cofilin Pathway” and “Method and System for Inactivating Virus Infectivity for Producing Live-Attenuated Vaccines.” Wu has devoted his career to HIV research. In 2013, he founded the biotech company Virongy after licensing an HIV drug-screening technology that was developed in his Mason lab.

“The Office of Technology Transfer takes great pride in the quality of patented innovations brought forth by our dedicated researchers,” said David Grossman, senior director of Technology Transfer and Industry Collaboration at Mason. “We are honored to help these innovators transition their groundbreaking concepts from the laboratory to the marketplace. This collaboration between academia and industry underscores our unwavering commitment to harness the full potential of research for the betterment of society.”

The academy’s Top 100 lists are created using data provided by the U.S. Patent and Trademark Office. Other Virginia universities in the top 100 included University of Virginia at 52 and Virginia Commonwealth University at 86.

According to the National Academy of Inventors press release, “This new list was created to highlight and celebrate American innovation and to showcase the universities that play a large role in advancing the innovation ecosystem within the U.S. and beyond.”

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In This Story

Andre Marshall, PhD

Holly Matto, PhD, LCSW-C

Lance A. Liotta

Duminda Wijesekera

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Innovation Awards celebrate Mason researchers

Colleen Rich — Fri, 02 Jun 2023 13:57:40 +0000

Innovation Awards celebrate Mason researchers Colleen Rich Fri, 06/02/2023 - 09:57

On May 9, ��AV celebrated its research enterprise with Innovation Awards, recognizing the Innovator of the Year and a Mason start-up, and those who received and/or licensed a patent.

Michael Buschmann's team accepted the Innovator of the Year award from Vice President Andre Marshall (holding plaque) on his behalf. Photo by John Boal Photography

According to David Grossman, senior director of technology transfer and industry collaboration in Mason’s Office of Research, Innovation, and Economic Impact, this was the first time since 2010 that the university formally recognized researchers. Going forward it will be an annual event.

“At the Mason Innovation Awards, we were privileged to recognize the tireless pursuit of knowledge and the transformative impact of our faculty’s discoveries,” said Grossman. “Through their dedication, these researchers are helping shape the world with their groundbreaking technologies and pushing the boundaries of what is possible."

The Innovator of the Year Award was awarded posthumously to Michael Buschmann, Eminent Scholar and the former chair of the Bioengineering Department within Mason’s College of Engineering and Computing. Buschmann help found the start-up AexeRNA Therapeutics Inc., in partnership with the university’s Office of Technology Transfer. He and his team licensed the commercial rights of four patents to the company. The technology AexeRNA is working on will make mRNA vaccines less costly and more readily available worldwide. Members of Buschmann’s AexeRNA team were recognized at the ceremony.

Saleet Jafri was awarded the Mason Start-up Award. Photo by John Boal Photography

The Mason Start-up Award was presented to Saleet Jafri, director of Mason’s Interdisciplinary Program in Neuroscience and professor in the School of Systems Biology, College of Science, for his company Pathodynamics. Pathodynamics has licensed three Mason patents and is developing a technology that solves the problem of cancer drug resistance, which is responsible for more than 90% of cancer deaths. Jafri has also received a Small Business Innovation Research award for the technology and is working with the Virginia Small Business Development Center’s Innovation Commercialization Assistance Program (ICAP).

University Professor Lance Liotta, cofounder and codirector of the Center for Applied Proteomics and Molecular Medicine, was recognized with a Mason Lifetime Disclosure Award. During his career, Liotta has filed more than 120 patent disclosures. Disclosures are the first step toward a patent by making a public claim about an invention or discovery. Liotta has 100 inventions to date and the prototype of one of these inventions—Laser Capture Microdissection, a method to procure subpopulations of tissue cells under direct microscopic visualization—is in the Smithsonian Institution’s collection.

Lance Liotta (left) and David Grossman holding Liotta's Lifetime Disclosure Award. Photo by John Boal Photography

During the program, Gisele Stolz, senior director of Entrepreneurship and Innovation Programs at Mason, was recognized for recently receiving an Impact Award from the Commonwealth Cyber Initiative for mentoring students. Stolz has helped place more than 150 Mason students in internships with cyber-related start-ups.

Participants of the Virginia SBDC ICAP and national I-CORPS programs and Mason researchers who have patented or licensed a technology or invention were also recognized.

The awards for patents and licensed technologies are Plexiglas hexagons with magnets so researchers can add to their award over the years as they receive patents/licensing.

A list of those Mason researcher licensing technologies follows.

Mason Licensed Technology Awards

“Microscopic Particles for Target Bio-markers,” licensed to Ceres NanoSciences
Lance Liotta, Emanuel Petricoin, Alessandra Luchini Kunkel, Barney Bishop, Virginia Espina, Marissa Howard, and Fatah Kashanchi

“Self-Cleaning Intrusion Tolerance” licensed to SCIT Labs
Arun Sood

“Pre-Shot Sniper Detection” licensed to First Guard Technologies
Kenneth J. Hintz

“Cauldron” licensed to Cyvision Technologies
Sushil Jajodia

“Antiretroviral Compositions” licensed to Lentx
Yuntao Wu

“Biological Materials” licensed to Kera FAST
Barney Bishop, Monique van Hoek, Robin Couch, and Yuntao Wu

“Atomic Magnetometer” licensed to Twinleaf
Karen Sauer

“Protein–Protein Interactions” licensed to EMD Millipore
Alessandra Luchini Kunkel, Lance Liotta, and Virginia Espina

“Antiretroviral Cyclonucleotides” and “Pseudovirus Platform” licensed to Virongy
Yuntao Wu and Brian Hetrick

“Packet Flow Watermarking” licensed to CyberRock Tech
Xinyuan Wang

“Encryption IP Cores” licensed to Chaologix
Gaj Krzysztof and Panasayya Yalla

“Personalized Therapy” licensed to Avant Diagnostics
Emanuel Petricoin and Julia Wulfkuhle

“Thromboembolism Sleeve” licensed to Phase II Consulting and Staffing
Lance Liotta and Marissa Howard

“Laser Capture Microdissection” and “Tissue Molecular Profiling” licensed to Targeted Biosciences
Lance Liotta, Alessandra Luchini Kunkel, Virginia Espina, Amanda Nicole Haymond Still, Marissa Howard, and Philip Andrew Pappalardo

“Cancer and HIV Therapeutics” licensed to Targeted Pharmaceuticals
Catherine DeMarino, Fatah Kashanchi, Lance Liotta, and Virginia Espina

“HIV Vaccine” licensed to Viropeutics
Yuntao Wu

“Protein Painting” licensed to Monet Pharmaceuticals
Alessandra Luchini Kunkel, Amanda Nicole Haymond Still, Lance Liotta, Mikell Paige, and Virginia Espina

“Antidepressant Selection” licensed to Teahorse
Farrokh Alemi

“Honeybee Hive Therapy” licensed to Tri-State Proteomics
Alessandra Luchini Kunkel, Lance Liotta, and Rocio Solange Prisby

“mRNA Delivery Lipids” licensed to AexeRNA Therapeutics
Michael Buschmann, Mikell Paige, Suman Alishetty, and Manuel Carrasco

“COVID Contact Tracing” licensed to Vericord
Farrokh Alemi and Janusz Wojtusiak

“Wearable Devices for Managing Substance Abuse” licensed to LifeSpan Digital Health
Holly C. Matto and Padmanabhan Seshaiyer

“Precision Oncology” licensed to Pathodynamics
Mohsin Saleet Jafri and Soukaina Amniouel

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Social Work associate professor registers U.S. patent to reduce substance use relapse, the department’s first patent

Mary Cunningham — Wed, 26 Apr 2023 15:20:43 +0000

Social Work associate professor registers U.S. patent to reduce substance use relapse, the department’s first patent Mary Cunningham Wed, 04/26/2023 - 11:20

In This Story

Holly Matto, PhD, LCSW-C

Padmanabhan Seshaiyer

Substance use disorder affects more than 46 million Americans according to the 2021 National Survey on Drug Use and Health. Recovery can be a difficult path, but an interdisciplinary team led by Holly Matto, associate professor in the Department of Social Work, aims to make it a little easier through a recently patented technology-based recovery support system.

Matto and College of Science Professor Padmanabhan Seshaiyer received the patent for a mobile technology to help those in recovery overcome triggers that lead to relapse. The technology is a real-time, cloud-based support system that helps manage behavioral responses—for example, the desire to use opioids—by monitoring physical symptoms, such as changes to a person’s heart rate, to identify when someone needs help to overcome a triggering event. With up to 60 percent of patients experiencing relapse within one year of treatment, the support is critical.

“The patent recognizes our unique contribution to the expanding availability of digital health technologies designed to improve access to timely support,” says Matto. The patent is believed to be the first received by a faculty member from the Department of Social Work.

Known as Recovery Engaged Mind-Health (REMind-h), the technology allows individuals in recovery to identify personally meaningful recovery-affirming sensory cues, which might include positive images, sounds, or other sensory stimuli that reinforce their commitment to recovery. Some examples might include peaceful nature scenes, a soundscape, motivational quote, or a sponsor’s message. These data are stored in the system’s cloud server and are activated and delivered to the person when their physiological metrics rise above the trained threshold, cycling through the available cues until regulation is restored.

“By using technology to monitor physiological responses, people in recovery can immediately have a personalized support system right there on their phone when they need it to help them manage the triggering moment,” says Matto. “The goal is to avoid relapse and, ultimately, to improve their quality of life.”

Matto says the patent has allowed the research team to partner with LifeSpan Digital Health LLC, which will license the technology. The technology prototype has already been developed by Rudra Nagalia, a graduate student in Health Administration and Policy and a member of the research team.

Matto began work on the idea behind the patent several years ago. She and Seshaiyer first teamed up to develop the technology after receiving a multidisciplinary grant from the provost’s office in 2015. They were selected for Mason’s National Science Foundation Innovation Corps Site Program in 2018, where they conducted interviews and gathered preliminary feedback on the concept.

Since then, Matto and Seshaiyer have also received a National Institutes of Health Small Business Technology Transfer sub-award to further test some of their recovery cue ideas. Bryce Dunn, PhD student in bioengineering, worked with the team on the grant to examine the regulating impact of recovery cues after exposure to substance-related cues in a virtual reality simulation. College of Engineering and Computing faculty member Nathalia Peixoto, a member of this interdisciplinary research team, offered expertise in measuring physiological and neural responses in the VR simulation, to help test the theory that personalized recovery cues help regulate reactivity to drug-stimuli exposures.

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public health research

Research

Retro Mason: Mason’s First Patent 1996

Colleen Rich — Tue, 31 May 2022 12:12:33 +0000

Retro Mason: Mason’s First Patent 1996 Colleen Rich Tue, 05/31/2022 - 08:12

Photo by Evan Cantwell/Creative Services

In the 1990s, Jenefir Isbister, a research professor in the Department of Molecular and Microbiology in ��AV’s then College of Arts and Sciences, was asked if it was possible to develop a quick, portable, and accurate tool to detect pathogens in liquids. Her answer produced Mason's first patent for her invention of a test for microbial contamination. The paperwork for “Biological assay for microbial contamination” was filed on May 27, 1994, and awarded August 27, 1996.

Isbister, now retired from Mason and a professor emerita of molecular and microbiology, followed up with additional research that led to a second patent in 1999 and the development of commercially produced biological test kits for total viable bacteria, coliforms and Escherichia coli. The test kit for total viable bacteria, known as Kool Kount Assayer, was manufactured and marketed by Maryland-based IME Inc.

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Mason professor Mahesh P. Joshi aims to license his business strategy game

Colleen Rich — Tue, 03 Mar 2020 10:00:34 +0000

Mason professor Mahesh P. Joshi aims to license his business strategy game Colleen Rich Tue, 03/03/2020 - 05:00

In This Story

Maheshkumar P. (Mahesh) Joshi

School of Business professor Mahesh P. Joshi created BiggieBills after searching for years for an interactive strategy game to use in his classes. Photo by Lathan Goumas/Office of Communications and Marketing.

The idea came to him in the middle of the night during a cruise with family and friends. He spent the next day in the cabin, writing out the rules for a novel business strategy board game.

Despite being on vacation, Mahesh P. Joshi, associate professor of global strategy and entrepreneurship at ��AV’s School of Business, recruited his family and friends to test out the card game. In the middle of playing, Raj S. Davé, a family friend and patent lawyer, suddenly said, “We need everyone to sign confidentiality agreements before we continue playing.”

And that’s how Joshi knew he had invented something different. In December 2019, the U.S. Patent and Trademark Office agreed and granted a patent for BiggieBills, a complex interactive strategy game designed for executive training, company retreats and business classes. BiggieBills will be available for licensing agreements in May, once the game is digitalized.

“The idea that I should create a game to help people better understand complex business strategy had been festering in my brain for a while,” said Joshi. “But the details of what that game would be came together at once, and I had to rush to get it down.”

BiggieBills is a business strategy game that is played in teams. Photo by Lathan Goumas/Office of Communications and Marketing.

Joshi was the founding director of Mason’s Center for Innovation and Entrepreneurship and recently served as its director of research and practice. In addition to teaching Mason students and research, Joshi advises and provides consulting to the public-sector, private-sector and not-for-profit organizations about corporate entrepreneurship and strategic and cross-cultural business management.

Joshi is introducing BiggieBills in the classes he teaches, including executive training sessions for companies and government agencies. In addition, he’s marketing the game to other business schools and executive training programs.

BiggieBills is a “team game that is fast paced, has an explicit goal and evolves in a dynamic competitive context,” said Roy W. Hinton, former associate dean of executive education at the School of Business who encouraged Joshi to develop BiggieBills. “It generates great team discussions about appropriate moves, and players quickly see the impact of their decisions.”

BiggieBills is played in teams, and can be adapted to include as many as 50 players. Each team takes on the role of an established business trying to gain the top position in a chosen industry. The standard game lasts about three hours, and a crucial point in the learning process occurs when the game facilitator debriefs at the end.

The game is focused on business strategy, but can be modified to include other topics, such as entrepreneurship, new product development and sales management. The two main ways to win are to be the first team to earn a billion dollars or to be the last remaining team standing after all others have declared bankruptcy.

Davé, president of the Davé Law Group in Alexandria, Virginia, said that the game is a teaching tool that is fun to play.

“Why is it fun? It’s influenced by luck and strategy, just like life. You can win or lose, just like in life,” said Davé, who helped Joshi obtain the patent on his game.

Joshi said he created BiggieBills after searching for years for an interactive strategy game to use in his class, but not liking what he found.

“There’s no game like this around,” said Joshi. “If there had been, I would have used it in my classes, and wouldn’t have had to invent it.”