Clinical Research

New coaching course in the College of Public Health motivates students of all majors

Shayla Brown — Mon, 03 Mar 2025 14:58:30 +0000

New coaching course in the College of Public Health motivates students of all majors Shayla Brown Mon, 03/03/2025 - 09:58

��AV recently welcomed Martin Binks as professor and chair of the Department of Nutrition and Food Studies. He brought a new special topics course with him to the College of Public Health: NUTR 594 or “Motivation: Learning to Coach.”

Martin Binks. Photo by Mary Cunningham/College of Pubic Health.

“[The topic] is rooted in health coaching, specifically for improving health, overall quality of life and well-being, but the skillset that we teach is very applicable across various professions business settings, and so forth,” said Binks, who has a PhD in clinical psychology and behavioral medicine.

With more than 20 years’ experience working with patients, he has typically done work under the umbrella of the organizations that he works for, Binks said his career has been about building new clinical and research programs where they didn't exist or improving those that were already in place.

He started with a health coaching program at the Duke Diet and Fitness Center, where he was a director of behavioral health, research, and new business and strategic alliances, and continued his work at Texas Tech University where he founded a clinical research institute, the Nutrition and Metabolic Health Initiative.

“There are lots of theories in psychology—self-determination theory, self-efficacy theory, cognitive behavioral theory—so how do we use these theories and translate that into tools that we use to motivate people?” he said. That is the question that his course aims to address.

The graduate course doesn’t require any pre-requisites and provides an unwavering client- focused approach to motivating and empowering people, Binks said, redefining the relationship between medical professionals and their clients, who benefit from having control and autonomy over their own health goals.

Kathryn Tadio. Photo provided.

While techniques such as motivational interviewing are commonly taught in medicine and used to understand how to motivate an individual person specific to their needs, Binks said this class teaches so much more.

“A coach’s primary tool is questions,” he said, “because it’s about the person in front of you. We often, especially in health care, assume that we know everything and the patient doesn't. That’s the worst thing we can do.”

Kathryn Tadio, MS Nutrition ’18, is an adjunct professor in the Department of Nutrition and Food Studies and is taking the course as a nondegree student.

“I am counseling clients now, and I'm already learning how to apply this course material with them. Having this resource has been really beneficial,” said Tadio, a registered dietitian who works for Dietitian Live, a telehealth program.

The first assignment students receive is an improv assignment, allowing students to practice thinking and speaking on their feet, which is a great tool for a coach.

Students provided verbatim transcripts, and then used a dictation software to edit the scripts and analyze their own conversations.

One of the cons with the class is that students might think they’re just having a normal conversation because it appears so natural, Binks explained, it takes time to fully appreciate the depth of thought that a coach brings to each and every choice they make in that conversation.

Two women having a discussion. Photo by Getty Images

“The assignment was so well thought out and it involved a lot of role playing and practicing what we're learning with fictitious clients. We were asking questions around people's triggers, for example, what makes them eat even when they're not hungry,” said Tadio. “That’s definitely something that I’d tiptoe around with actual clients, so it's good to practice with those questions now because it really lowers the risk of miscommunication or mistakes in the real world.”

The asynchronous aspect of the course provides an interesting real-life element, Binks said. Students practice their new skills in role play assignments.

“We’re online, but the assignments require the students go out into their personal world talking to their friends and family and coaching them,” said Binks. With these assignments, students learn and practice the necessary complex skill sets that they can then apply to pretty much any field they want.”

Tadio was pleased to have access to such a resource. “I’m really happy to see how George Mason’s nutrition department has grown since I was a student. Now they offer the registered dietitian track and courses like this one, which will make more well-rounded health care professionals.”

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Martin Binks PhD, MBA

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A biofilm epic in the making

Rena Malai — Wed, 12 Oct 2022 14:09:34 +0000

A biofilm epic in the making Rena Malai Wed, 10/12/2022 - 10:09

There are a lot of ways to cut film, as many cinemas and directors can attest. But biofilms—which settle on numerous surfaces, including skin—can contain harmful bacteria and get in the way of healing wounds.

Mason researchers Jeffrey Moran, Rémi Veneziano, and Monique van Hoek, Photo by Evan Cantwell/Creative Services

Assistant Professors Jeffrey Moran in the Department of Mechanical Engineering and Rémi Veneziano in the Department of Bioengineering at George Mason have a shared interest in using nanotechnology for medical applications, as well as a shared history. Both worked as postdocs at the Massachusetts Institute of Technology, but it wasn’t until they started working at Mason that their paths crossed. Partnering up with Professor Monique van Hoek, a microbiologist in the School of Systems Biology at George Mason, they applied for and recently won the National Institute of Biomedical Imaging and Bioengineering (NIBIB) R21 Trailblazer award.

Through the award funds, the team will use their backgrounds and spend about three years developing a brand-new technology that dissolves harmful biofilms, without harsh removal methods.

“You can think of a biofilm as a ‘city for microbes.’ Biofilms are functional communities of microorganisms, such as bacteria, encased in a slime-like matrix,” says Moran. “Bacterial biofilms often grow on catheters, IVs, open wounds, burn injuries, and more, and they play a major role in many hospital infections. We’re going to develop a safe and effective method to remove topical biofilms that doesn’t get in the way of the body’s natural healing process.”

Some biofilms are relatively benign, and many folks have them on the surfaces of their teeth. But harmful biofilms can develop throughout the body for many reasons, like on the skin surface as a result of trauma, and cause potentially fatal infections.

Moran’s primary research focus is on “nanoswimmers"—tiny particles that propel themselves in liquids or biological media. Many researchers are developing them to use in the body, to deliver therapeutic payloads (like antibiotics) to hard-to-reach locations.

“One major challenge with bacterial biofilms is how to make them disassemble," says van Hoek. “There are three major parts to a biofilm—DNA, protein, and complex sugars. Destroying any one of these three things often leads to biofilm collapse. My idea was to use a sugar cleaving enzyme to attack the sugars in the biofilm, and to attach this enzyme to the front of the nanoswimmers so that they can drill deep into the biofilm.”

“What we’re trying to do is develop self-propelled particles that penetrate deep into the thick matrix of the biofilm, dissolving it and also serving as a carrier to deliver antibiotics at the same time,” says Veneziano.

To manufacture the self-propelled particles, the team is relying on Veneziano’s specialty: DNA origami, which is a method that involves precisely assembling DNA molecules into tiny two- and three-dimensional shapes.

“With DNA origami, you have the ability to produce tailor-made particles with phenomenal control over the size, shape, and the cargo they carry," says Veneziano. "DNA origami’s versatility will enable the particles to be decorated with various cargoes, such as antibiotics or enzymes that dissolve the biofilm matrix, leaving the bacteria vulnerable to conventional antibiotic treatments.”

Although using enzymes to dissolve the biofilms isn’t new, attaching them onto DNA origami nanoparticles is, which is the trailblazing path Veneziano, van Hoek and Moran will follow.

“It all started with a ‘what if we tried this?’ type of conversation. We bounced ideas off each other, talking about ways we might make DNA nanoparticles swim, and how that capability might be useful in certain medical situations. That back-and-forth eventually led to this award,” says Moran. “We’re excited to get started.”

The R21 Trailblazer Award is an opportunity for new and early-stage investigators to pursue research programs of high interest to the NIBIB at the interface of the life sciences with engineering and the physical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk/high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven.